Kayaflavone
Based on 1 Customer Validation
Kayaflavone is a biflavonoid compound from the seed kernel of Torreya grandis. Kayaflavone exhibits anticancer activity and is cytotoxic to human tumor cell lines. Kayaflavone inhibits amyloid-β toxicity in PC-12 cells with an EC50 of 5.29 μM. Kayaflavone is predicted to bind to the catalytic site of the SARS-CoV-2 main protease (Mpro/3CLpro) and block enzyme activity, indicating potential antiviral activity. Kayaflavone can be used in cancer-related research, such as cervical cancer and breast cancer, as well as in research related to neurological diseases.
For research use only. We do not sell to patients.
- Purity : 96.0%
- CAS No.: 481-45-8
- Formula: C33H24O10
- Molecular Weight:580.54
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
3.26 μg/mL
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Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
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MGC-220077 |
| MCF7 | IC50 |
12.64 μg/mL
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Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
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MGC-220077 |
| PANC-1 | IC50 |
16.44 μg/mL
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Cytotoxicity against human pancreatic cancer PANC-1 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
Cytotoxicity against human pancreatic cancer PANC-1 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
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MGC-220077 |
| HepG2 | IC50 |
8.67 μg/mL
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Cytotoxicity against human hepatocellular carcinoma HepG-2 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
Cytotoxicity against human hepatocellular carcinoma HepG-2 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.
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MGC-220077 |
In Vitro
Kayaflavone (compound 2) (0.01-100 µg/mL; 48 h) exhibits cytotoxic activity against HeLa, MCF-7, PANC-1, and HepG-2 cells, with IC50 values of 3.26, 12.64, 16.44, and 8.67 µg/mL, respectively, among which the activity against HeLa is the strongest[1].
Kayaflavone (compound C9) (molecular docking simulation) yields a high predicted binding score (‑9.0351) against the SARS‑CoV‑2 main protease MPRO[2].
Kayaflavone (compound 15) inhibits amyloid-β toxicity in PC-12 cells, with an EC50 of 5.29 μM, and cell viability reaches 80.5% at 10 μM[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, MCF-7, PANC-1, and HepG-2
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Concentration:0.01, 0.1, 1.0, 10.0, 100.0 µg/mL
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Incubation Time:48 h
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Result:Showed IC50 values of 3.26 µg/mL against HeLa, 12.64 µg/mL against MCF-7, 16.44 µg/mL against PANC-1, and 8.67 µg/mL against HepG-2.
Chemical Information
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CAS No. 481-45-8
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Appearance Solid
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Molecular Weight 580.54
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Formula C33H24O10
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Color Light yellow to yellow
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SMILES
O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)OC)=C(OC)C=C2)OC6=C1C(O)=CC(O)=C6
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kayaflavone Related Classifications
HY-N9861 Related Classifications
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