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Cat. No.: HY-186286

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KRAS-IN-63

KRAS-IN-63 is a KRAS^G12 inhibitor with a pIC₅₀ of 8.11. KRAS-IN-63 can be used in lung cancer-related research.

For research use only. We do not sell to patients.

Formula: C₃₁H₃₁ClN₆O₂
Molecular Weight:555.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-63 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRAS-IN-63 is a KRAS^G12 inhibitor with a pIC₅₀ of 8.11. KRAS-IN-63 can be used in lung cancer-related research^[1].

IC₅₀ & Target^[1]

KRASG12

8.11 (pIC₅₀)

All Ras Isoforms :

In Vitro

KRAS-IN-63 (C9) tightly docks into the Switch-II pocket of KRAS^G12C, and forms a network of hydrogen bonds, electrostatic interactions and hydrophobic interactions with key pocket residues (SER17, THR35, ASP33)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 555.07
Formula C₃₁H₃₁ClN₆O₂
SMILES

O=C1N(C2=C[C@]([C@]3=C4C(NN=C4)=CC=C3C)=C(C=C2C(N5CCN(CC5)C(C)=O)=N1)Cl)C6=C(C=CC=C6)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stephen Adebayo O, et al. QSAR-guided discovery of novel KRAS inhibitors for lung cancer therapy. Frontiers in bioinformatics. 2025;5:1663846. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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KRAS-IN-63

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS-IN-63 Related Classifications

HY-186286 Related Classifications