Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells

  • Chem Biodivers. 2008 Dec;5(12):2710-7. doi: 10.1002/cbdv.200890225.
Quan-Bing Han  1 ,  Hong-Lei Tian ,  Nian-Yun Yang ,  Chun-Feng Qiao ,  Jing-Zheng Song ,  Donald C Chang ,  Kathy Q Luo ,  Hong-Xi Xu
Affiliations
  • 1. Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N. T., Hong Kong, P. R. China.
PMID: 19089829 DOI: 10.1002/cbdv.200890225
Abstract

Three new prenylated Xanthones, 1-3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a Caspase sensor protein.

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