Trigoxyphin A
Trigoxyphin A is a oxygenated daphnane-type diterpenoids. Trigoxyphin A exhibites strong cytotoxic activity against HL60 and A549 with IC50s of 0.27 and 7.5 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1236874-00-2
- Formula: C34H34O9
- Molecular Weight:586.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
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[PMID: 21192108] |
| A549 | IC50 |
7.5 μM
Compound: 1
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Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
|
[PMID: 20593838] |
| Bel-7402 | IC50 |
>10 μM
Compound: 1
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Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay
Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay
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[PMID: 20593838] |
| HL-60 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
|
[PMID: 21192108] |
| HL-60 | IC50 |
0.27 μM
Compound: 1
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
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[PMID: 20593838] |
| MCF7 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay
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[PMID: 21192108] |
Chemical Information
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CAS No. 1236874-00-2
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Molecular Weight 586.63
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Formula C34H34O9
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SMILES
C[C@H]1[C@]23[C@]([C@H]4[C@](O4)([C@H]([C@]5([C@@]3([H])C=C(C5=O)C)O)O)C)([H])[C@]6([H])[C@]([C@H]1OC(C7=CC=CC=C7)=O)(O[C@](O6)(C8=CC=CC=C8)O2)C(C)=C
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trigoxyphin A Related Classifications
HY-N10082 Related Classifications
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