DMA-132
DMA-132 is a translation inhibitor and antiviral agent. DMA-132 can target and bind to the conserved RNA stem-loop (bulge structure) in the 5'-UTR of SARS-CoV-2, thereby blocking viral RNA translation and replication. DMA-132 can be used in research related to coronavirus disease 2019 (COVID-19) and coronavirus infections.
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- CAS. Nr.: 1160-14-1
- Formel: C14H17N7O
- Molecular Weight:299.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero E6 | CC50 |
>100 μM
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Cytotoxicity against Vero E6 cells assessed as reduction in cell viability incubated for 96 hrs at 33°C by MTT assay.
Cytotoxicity against Vero E6 cells assessed as reduction in cell viability incubated for 96 hrs at 33°C by MTT assay.
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34826236 |
In Vitro
DMA-132 (50-100 μM; 24 h) reduces the viral titer by approximately 1000-fold in Vero E6 cells infected with hCoV OC43[1].
DMA-132 (1 μM-1 mM; 24-72 h) reduces infectious virus titers and decreases viral RNA levels in cell supernatants in a dose-dependent manner in SARS-CoV-2-infected Vero E6 cells[1].
DMA-132 (0.1-100 μM; 48 h) reduces 5'-UTR-dependent luciferase expression in Vero E6 cells co-transfected with the SARS-CoV-2 5'-UTR-FLuc luciferase reporter gene[1].
DMA-132 (500 μM) specifically binds to RNA structures (mainly the internal bulge regions of SL1, SL4, SL5a and SL6) in a cell-free system[1].
DMA-132 (1 μM-1 mM; 96 h) exhibits extremely low cytotoxicity in Vero E6 cells, with a CC50 > 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero E6 cells
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Concentration:0.01 nM, 0.1 nM, 1 nM, 0.01 μM, 0.1 μM, 1 μM, 10 μM, 100 μM, 1 mM
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Incubation Time:96 h
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Result:Did not substantially reduce cell viability at concentrations < 100 μM, revealing a 50% cytotoxic concentration (CC50) of > 100 μM.
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Cell Line:Vero E6 cells
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Concentration:1 μM, 10 μM, 100 μM, 1 mM
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Incubation Time:24, 48, 72 h
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Result:Dose-dependently decreased cell-free viral RNA levels in supernatants of infected cells.
Chemical Information
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CAS. Nr. 1160-14-1
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Molecular Weight 299.33
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Formel C14H17N7O
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SMILES
O=C(C1=C(N)N=C(N(C)C)C(C2=CC=CC=C2)=N1)NC(N)=N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DMA-132 Related Classifications
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