Doconexent sodium
Based on 50 publication(s) in Google Scholar
Doconexent sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.80%
- CAS 番号: 81926-93-4
- 分子式: C22H31NaO2
- 分子量:350.47
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
MedChemExpress(MCE)の使用を引用している文献 Doconexent sodium
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Science. 2025 Mar 14;387(6739):eadm9805. [Abstract]
- Nat Biotechnol. 2025 Feb 5:10.1038/s41587-025-02556-5. [Abstract]
- Cell Metab. 2026 Mar 3;38(3):565-581.e5. [Abstract]
- Drug Resist Updat. 2025 Jul:81:101224. [Abstract]
- Nat Commun. 2022 Feb 17;13(1):931. [Abstract]
- J Adv Res. 2026 Mar 9:S2090-1232(26)00224-9. [Abstract]
- Redox Biol. 2023 Oct:66:102857. [Abstract]
- Gut Microbes. 2023 Dec;15(2):2265578. [Abstract]
- Adv Sci (Weinh). 2025 Aug 29:e17049. [Abstract]
- Chem Eng J. 2025 Oct 17;524:169708.
- Pharmacol Res. 2026 Apr 30:108225. [Abstract]
- Cell Death Dis. 2021 Jan 12;12(1):73. [Abstract]
- Cell Death Dis. 2020 Sep 15;11(9):756. [Abstract]
- Phytomedicine. 2023 Jul 25:116:154825. [Abstract]
- Acta Pharmacol Sin. 2025 Jun 23. [Abstract]
- Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118. [Abstract]
- Food Res Int. 2025 May:208:116218. [Abstract]
- Free Radic Biol Med. 2023 Jun:202:110-120. [Abstract]
- Cancer Immunol Res. 2022 Dec 2;10(12):1542-1558. [Abstract]
- Cancer Immunol Res. 2024 Jun 4;12(6):744-758. [Abstract]
- Cell Rep. 2026 Jun 25;45(7):117613. [Abstract]
- Cell Rep. 2025 Nov 25;44(11):116496. [Abstract]
- JCI Insight. 2021 Oct 22;6(20):e151911. [Abstract]
- Talanta. 2021 Nov 1:234:122631. [Abstract]
- Food Funct. 2024 Nov 11;15(22):11236-11251. [Abstract]
- Food Funct. 2020 Oct 21;11(10):8893-8904. [Abstract]
- Mar Drugs. 2023 Feb 25;21(3):155. [Abstract]
- Int Immunopharmacol. 2023 Jan:114:109544. [Abstract]
- Int J Mol Sci. 2022 May 10;23(10):5323. [Abstract]
- Sci Rep. 2026 Apr 9;16(1):16713. [Abstract]
- Mol Nutr Food Res. 2026 Jun;70(11):e70522. [Abstract]
- Fish Shellfish Immunol. 2019 Nov:94:199-210. [Abstract]
- J Biol Chem. 2023 Jul;299(7):104909. [Abstract]
- ACS Pharmacol Transl Sci. 2025 Oct 4;8(11):4095-4106. [Abstract]
- Clin Exp Immunol. 2025 Jan 21;219(1):uxaf055. [Abstract]
- Pathol Res Pract. 2020 Feb;216(2):152795. [Abstract]
- Toxicol Appl Pharmacol. 2026 Mar 4:511:117777. [Abstract]
- J Dent Sci. 2025 Jan;20(1):444-451. [Abstract]
- Int J Parasitol Drugs Drug Resist. 2024 Aug:25:100551. [Abstract]
- Biologia. 2023 Jan 24.
- Res Sq. 2026 Jan 15.
- Res Sq. 2025 Nov 19:rs.3.rs-7983397. [Abstract]
- Biomed Pharmacother. 2025 Oct:191:118495. [Abstract]
- SSRN. 2025 Apr 27.
- Res Sq. 2024 Aug 16.
- bioRxiv. 2024 Jun 12:2024.06.11.598533. [Abstract]
- Research Square Preprint. 2023 Oct 10.
- Oxid Med Cell Longev. 2022 Sep 9;2022:8672969. [Abstract]
- Universitat Politècnica de València. 2020 Sep.
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WB
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ELISA
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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In Vivo Efficacy Study
生物活性
化学情報
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CAS 番号 81926-93-4
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性状 Solid
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分子量 350.47
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分子式 C22H31NaO2
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Color White to off-white
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SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O[Na])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (50)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Science
2025 Mar 14;387(6739):eadm9805. PMID: 40080571
Doconexent sodium purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805. [Abstract]
Immunoblot analysis of HCC1806 cells following 16 hour serum starvation and subsequent stimulation with 10% FBS or 30 μM ω-6 LA or arachidonic acid (AA), or ω-3 ALA, eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) for 30 minutes.
Doconexent sodium purchased from MedChemExpress. Usage Cited in: Science. 2025 Mar 14;387(6739):eadm9805. [Abstract]
HCC1806 cells were serum starved for 16 hours and subsequently restimulated for 30 minutes with 1μM, 5μM, 10μM, 30μM, 100μM, 200μM, 1000μM of ω-6 LA, ω-6 ARA, ω-3 ALA, ω-3 EPA and ω-3 DHA for 30 minutes. Intracellular concentrations of each PUFA were quantified by ELISA from lysates obtained from 5 x 106 cells.
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Nat Biotechnol
Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. [Abstract]2025 Feb 5:10.1038/s41587-025-02556-5. PMID: 39910195 -
Cell Metab
Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy. [Abstract]2026 Mar 3;38(3):565-581.e5. PMID: 41570815 -
Drug Resist Updat
DTX2 attenuates Lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal β-oxidation in hepatocellular carcinoma. [Abstract]2025 Jul:81:101224. PMID: 40058099
Doconexent sodium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2025 Jul:81:101224. [Abstract]
MDA and GSH levels in Scramble/shHSD17B4 Huh7 and SNU-423 cells treated with DHA (25-150 μM).
Doconexent sodium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2025 Jul:81:101224. [Abstract]
BODIPY-C11 581/591 probe detection in Scramble/shHSD17B4 cells treated with Lenvatinib (Lenv) or DHA (25-150 μM). Scale bar, 40 μm.
Doconexent sodium purchased from MedChemExpress. Usage Cited in: Drug Resist Updat. 2025 Jul:81:101224. [Abstract]
A schematic diagram depicting the in vivo assessment of tumor xenografts generated by subcutaneous injection of Huh7-LR cells. DHA (7 g/kg, p.o.), n = 5 mice in each group.
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Nat Commun
Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. [Abstract]2022 Feb 17;13(1):931. PMID: 35177641 -
J Adv Res
2026 Mar 9:S2090-1232(26)00224-9. PMID: 41812706 -
Redox Biol
Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in radiation-induced intestinal injury. [Abstract]2023 Oct:66:102857. PMID: 37611494 -
Gut Microbes
PUFAs add fuel to Crohn's disease-associated AIEC-induced enteritis by exacerbating intestinal epithelial lipid peroxidation. [Abstract]2023 Dec;15(2):2265578. PMID: 37800577 -
Adv Sci (Weinh)
Reprogramming of Fatty Acid Metabolism via PPARα-Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis. [Abstract]2025 Aug 29:e17049. PMID: 40878384 -
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Pharmacol Res
Lysosome-triggered nanotherapy packages osteoclast apoptotic bodies with pro-anabolic lipids to couple anti-resorption and bone formation. [Abstract]2026 Apr 30:108225. PMID: 42069319 -
Cell Death Dis
DHA/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly. [Abstract]2021 Jan 12;12(1):73. PMID: 33436541 -
Cell Death Dis
Acyl-CoA thioesterase 1 prevents cardiomyocytes from Doxorubicin-induced ferroptosis via shaping the lipid composition. [Abstract]2020 Sep 15;11(9):756. PMID: 32934217 -
Phytomedicine
Alpha-linolenic acid improves nasal mucosa epithelial barrier function in allergic rhinitis by arresting CD4+ T cell differentiation via IL-4Rα-JAK2-STAT3 pathway. [Abstract]2023 Jul 25:116:154825. PMID: 37178572 -
Acta Pharmacol Sin
Ginsenoside (20)S-APPT induces ferroptosis in hepatocellular carcinoma and cholangiocarcinoma by targeting FSP1. [Abstract]2025 Jun 23. PMID: 40550962 -
Proc Natl Acad Sci U S A
2021 Oct 26;118(43):e2104689118. PMID: 34675076
Doconexent sodium purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118. [Abstract]
Eicosapentaenoic Acid . Western blot analysis showing the protein levels of HIF-1A, COL1A1, and α-SMA in HSFs treated with 5-20 μM DHA/EPA and under 21% (normoxic) or 5% (hypoxic) oxygen levels.
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Food Res Int
Effects of chitosan on restoring spermatogenesis in mice: Insights from gut microbiota and multi-omics analysis. [Abstract]2025 May:208:116218. PMID: 40263850 -
Free Radic Biol Med
Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma. [Abstract]2023 Jun:202:110-120. PMID: 36997100 -
Cancer Immunol Res
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy. [Abstract]2022 Dec 2;10(12):1542-1558. PMID: 36255412 -
Cancer Immunol Res
The ω-3 polyunsaturated fatty acid docosahexaenoic acid enhances NK-cell antitumor effector functions. [Abstract]2024 Jun 4;12(6):744-758. PMID: 38526128 -
Cell Rep
Type I unconventional protein secretion of the SARS-CoV-2 nucleocapsid protein promotes inflammatory cytokine release. [Abstract]2026 Jun 25;45(7):117613. PMID: 42360880 -
Cell Rep
A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential. [Abstract]2025 Nov 25;44(11):116496. PMID: 41166305 -
JCI Insight
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris. [Abstract]2021 Oct 22;6(20):e151911. PMID: 34491907 -
Talanta
Development of a novel analytical method for inflammation and immunity-related metabolites in serum based on liquid chromatography tandem mass spectrometry. [Abstract]2021 Nov 1:234:122631. PMID: 34364440 -
Food Funct
Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP-PS1 transgenic mice. [Abstract]2024 Nov 11;15(22):11236-11251. PMID: 39453315 -
Food Funct
Inhibition of voltage-gated K+ channels mediates docosahexaenoic acid-stimulated insulin secretion in rat pancreatic β-cells. [Abstract]2020 Oct 21;11(10):8893-8904. PMID: 32986050 -
Mar Drugs
Possible Role of Docosahexaenoic Acid in Response to Diarrhetic Shellfish Toxins in the Mussel Perna viridis. [Abstract]2023 Feb 25;21(3):155. PMID: 36976204 -
Int Immunopharmacol
Amelioration of central neurodegeneration by docosahexaenoic acid in trigeminal neuralgia rats through the regulation of central neuroinflammation. [Abstract]2023 Jan:114:109544. PMID: 36527885 -
Int J Mol Sci
Oral Administration of Omega-3 Fatty Acids Attenuates Lung Injury Caused by PM2.5 Respiratory Inhalation Simply and Feasibly In Vivo. [Abstract]2022 May 10;23(10):5323. PMID: 35628131 -
Sci Rep
2026 Apr 9;16(1):16713. PMID: 41957466 -
Mol Nutr Food Res
2026 Jun;70(11):e70522. PMID: 42281281 -
Fish Shellfish Immunol
Transcriptome analysis and the effects of polyunsaturated fatty acids on the immune responses of the critically endangered angtze sturgeon (Acipenser dabryanus). [Abstract]2019 Nov:94:199-210. PMID: 31499199 -
J Biol Chem
Mitochondrial folate metabolism-mediated α-linolenic acid exhaustion masks liver fibrosis resolution. [Abstract]2023 Jul;299(7):104909. PMID: 37307917 -
ACS Pharmacol Transl Sci
Ultrasensitive Profiling of Arachidonic Acid Metabolites Based on 5‑(Diisopropylamino)amylamine Derivatization-Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. [Abstract]2025 Oct 4;8(11):4095-4106. PMID: 41262585 -
Clin Exp Immunol
Docosahexaenoic acid mitigates experimental autoimmune prostatitis by inhibiting Th17 cell differentiation via the PPARγ/NF-κB/IL-17A pathway. [Abstract]2025 Jan 21;219(1):uxaf055. PMID: 40887935 -
Pathol Res Pract
Dihydroartemisinin inhibits the growth and invasion of gastric cancer cells by regulating cyclin D1-CDK4-Rb signaling. [Abstract]2020 Feb;216(2):152795. PMID: 31879047 -
Toxicol Appl Pharmacol
MiR-29a/DNMT3A axis participates in Dihydroartemisinin's suppression on lung adenocarcinoma: Implications for overcoming acquired resistance to EGFR-TKIs. [Abstract]2026 Mar 4:511:117777. PMID: 41791429 -
J Dent Sci
Periodontal inflammation potentially inhibits hepatic cytochrome P450 expression and disrupts the omega-3 epoxidation pathway in a murine model. [Abstract]2025 Jan;20(1):444-451. PMID: 39873042 -
Int J Parasitol Drugs Drug Resist
Lower micromolar activity of the antifungal imidazoles on the bacterial-type bifunctional aldehyde/alcohol dehydrogenase (AdhE) in Cryptosporidium parvum and in vitro efficacy against the zoonotic parasite. [Abstract]2024 Aug:25:100551. PMID: 38875756 -
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Res Sq
Dietary Polyunsaturated Fatty Acids Regulate Dendritic Cell Function via Nrf2-dependent Control of Ferroptosis. [Abstract]2025 Nov 19:rs.3.rs-7983397. PMID: 41333438 -
Biomed Pharmacother
Neonatal sevoflurane exposure disrupted fatty acids metabolism, leading to hypomyelination and neurological impairments. [Abstract]2025 Oct:191:118495. PMID: 40925233 -
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bioRxiv
Enabling non-viral DNA delivery using lipid nanoparticles co-loaded with endogenous anti-inflammatory lipids. [Abstract]2024 Jun 12:2024.06.11.598533. PMID: 38915627 -
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Oxid Med Cell Longev
Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF- κ B Signaling Pathways. [Abstract]2022 Sep 9;2022:8672969. PMID: 36120596 -
純度とドキュメンテーション
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データシート (235 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)