DOPE-PEG2000-KAA
DOPE-PEG2000-KAA (DOPE-PEG2000-Mal-CKAAKNK) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the KAA peptide. KAA peptide functions as a targeting ligand for specific cell or tissue recognition. DOPE-PEG2000-KAA is used for targeted drug delivery through liposome and nanoparticle surface modification.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
DOPE-PEG2000-KAA: surface modification of liposomes and nanoparticles for targeted drug delivery to specific cells or tissues.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-responsive membrane fusion for intracellular cargo release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces protein adsorption and immune clearance, and extends circulation half-life;
(3) KAA peptide; a targeting peptide that specifically recognizes and binds to receptors or markers on target cells, directing nanocarriers to desired tissues for enhanced drug accumulation and therapeutic efficacy while minimizing off-target toxicity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[DOPE-PEG2000-KAA]
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Synonyms
DOPE-PEG2000-Mal-CKAAKNK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)