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Cat. No.: HY-115562

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Dorrigocin A

Dorrigocin A is an analog of Migrastatin (HY-121452). Dorrigocin A can inhibit the carboxymethyltransferase involved in Ras processing and reverse the morphology of ras-transformed NIH/3T3 cells. Dorrigocin A is promising for research of anti-cancer and anti-arthritis agents.

For research use only. We do not sell to patients.

CAS No.: 158446-29-8
Formula: C₂₇H₄₁NO₈
Molecular Weight:507.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Dorrigocin A Chemical Structure

CAS No.: 158446-29-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	>100 μM Compound: 4a, dorrigocin A	Cytotoxicity against human mouse 4T1 cells Cytotoxicity against human mouse 4T1 cells	[PMID: 18684620]
4T1	IC₅₀	>100 μM Compound: 4a, dorrigocin A	Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay Inhibition of cell migration of mouse 4T1 cells after 4 days by scratch wound healing assay	[PMID: 18684620]
MDA-MB-231	IC₅₀	>100 μM Compound: 4a, dorrigocin A	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 18684620]
MDA-MB-231	IC₅₀	>100 μM Compound: 4a, dorrigocin A	Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay Inhibition of human MDA-MB-231 cell migration after 4 days by scratch wound healing assay	[PMID: 18684620]

Chemical Information

CAS No. 158446-29-8
Molecular Weight 507.62
Formula C₂₇H₄₁NO₈
SMILES

O=C(O)/C=C/CC/C=C/[C@H](OC)[C@@H](O)[C@H](C)/C=C(C)/[C@H](O)[C@H](C)C(CCCC(C1)CC(NC1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anquetin G, et al. Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal. Chemistry. 2008;14(5):1592-600. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Dorrigocin A

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Dorrigocin A Related Classifications

HY-115562 Related Classifications