DPPE-PEG2000-APRPG

DPPE-PEG2000-APRPG is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. APRPG peptide: Targeting/functional ligand-APRPG peptide is a tumor angiogenesis-targeting peptide that selectively binds to tumor vascular endothelial cells, achieving tumor-vascularized targeted delivery.

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