DPPE-PEG2000-CTT2

DPPE-PEG2000-CTT2 is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. CTT2 peptide: Targeting/functional ligand-the CTT2 peptide can specifically bind to matrix metalloproteinase 2 (MMP-2), which is highly expressed in the tumor microenvironment, achieving targeted delivery to the tumor microenvironment.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.