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Cat. No.: HY-187744A

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DPPE-PEG2000-NYZL1

Name: DPPE-PEG2000-NYZL1
Brand: MedChemExpress
SKU: HY-187744A
Availability: PreOrder

(Synonyms: DPPE-PEG2000-Mal-Cys-NYZL1)

DPPE-PEG2000-NYZL1 (DPPE-PEG2000-Mal-Cys-NYZL1) is a functionalized PEGylated phospholipid conjugate composed of three modular components: 1,2-dispalmitoyl-sn-glycerol-3-phosphate ethanolamine (DPPE) as a lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 2000 Da, and the NYZL1 peptide as a terminal targeting/functional ligand. DPPE-PEG2000-NYZL1 can be used in research on targeted drug delivery for bladder cancer, among other applications.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DPPE-PEG2000-NYZL1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

DPPE-PEG2000-NYZL1 is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. NYZL1 peptide: Targeting/functional ligand-NYZL1 peptide is a bladder cancer targeting peptide that specifically binds to bladder cancer cells, achieving targeted delivery to bladder cancer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DPPE-PEG2000-NYZL1]
Synonyms

DPPE-PEG2000-Mal-Cys-NYZL1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. CD47-targeted optical molecular imaging and near-infrared photoimmunotherapy in the detection and treatment of bladder cancer. Mol Ther Oncolytics. 2022 Jan 1;24:319-330. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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