DSPE-PEG2000-OTC

DSPE-PEG2000-OTC is mainly used for the surface functionalization and targeted delivery of liposomes and nanoparticles.
Structural composition and function of each component:
(1) DSPE: 1,2-distearate-sn-glycerol-3-phosphoethanolamine, containing two saturated C18 stearoyl chains, is an amphiphilic phospholipid. As a lipid anchoring group, it can stably insert into the lipid bilayer of liposomes or lipid nanoparticles, anchoring the entire molecule to the carrier surface;
(2) PEG2000: Polyethylene glycol with a molecular weight of approximately 2000 Da, acting as a hydrophilic spacer arm, enhances the water solubility and steric hindrance of the molecule, improves the stability of the carrier, and prolongs its circulation time in vivo. Simultaneously, it extends the terminal ligand away from the carrier surface, facilitating the recognition and binding of the ligand and receptor;
(3) OTC ligand: A click chemistry group that can be used in conjunction with tetrazine-containing compounds to achieve efficient labeling.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.