1. Protein Tyrosine Kinase/RTK
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  3. Eflapegrastim

Eflapegrastim 

Cat. No.: HY-P99913

Eflapegrastim is a humanized IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia.

For research use only. We do not sell to patients.

Eflapegrastim Chemical Structure

Eflapegrastim Chemical Structure

CAS No. : 1384099-30-2

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Description

Eflapegrastim is a humanized IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia[1].

In Vitro

Eflapegrastim has an IgG4 Fc fragment and short polyethylene glycol linker[1].
Eflapegrastim (5.5-88 mM; 4 min) binds to FcRn but not Fcγ receptors or C1q[1].
Eflapegrastim (0.000036-0.709 nmol/L; 54 h) induces bone marrow cell proliferation[1].
Eflapegrastim (10 μM; 1 h) binds FcRn and undergoes FcRn-mediated transcytosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Eflapegrastim (100 μg/kg; s.c.; single dose) decreases the duration of neutropenia (DN) and increases levels of G-CSF in serum and marrow in chemotherapy-induced neutropenic rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6NCrl mice (4-6 weeks old)[1]
Dosage: (1) 9, 26, 53, and 88 µg/kg; (2) 62 µg/kg
Administration: Subcutaneous injection; single dose
Result: Reduced chemotherapy-induced neutropenia.
CAS No.
SMILES

[Eflapegrastim]

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Eflapegrastim
Cat. No.:
HY-P99913
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