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Corticosterone

(Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B)
65 Cited Publications
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Based on 65 publication(s) in Google Scholar

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect.

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  • Purity: 99.77%
  • CAS No.: 50-22-6
  • Formula: C21H30O4
  • Molecular Weight:346.47
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Corticosterone Chemical Structure
    Corticosterone Chemical Structure
  • Experimental Validation Results for Corticosterone
  • Experimental Validation Results for Corticosterone
  • Experimental Validation Results for Corticosterone
  • Experimental Validation Results for Corticosterone
  • Experimental Validation Results for Corticosterone
CAS No.: 50-22-6
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  • Corticosterone Chemical Structure
    Corticosterone Chemical Structure
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    Corticosterone purchased from MedChemExpress. Usage Cited in: Cell Discov. 2025 May 13;11(1):46. [Abstract]

    Customer Validation
     Corticosterone (5 mg/kg, i.p., once daily for 3 weeks) in C57BL/6 mice. H&E staining and quantification of crypt depth.

  • 1/16

    Corticosterone purchased from MedChemExpress. Usage Cited in: Cell Discov. 2025 May 13;11(1):46. [Abstract]

    Customer Validation
     Corticosterone (5 mg/kg, i.p., once daily for 3 weeks) in C57BL/6 mice. EdU and Olfm4 co-staining quantification of EdU+ cells per crypt and the percentage of EdU+ Olfm4+ cells.

  • 1/16

    Corticosterone purchased from MedChemExpress. Usage Cited in: Cell. 2025 Jan 9;188(1):157-174.e22. [Abstract]

    Customer Validation
     Corticosterone (10 mM/50 μL, intradermal injection, single dose) induces widespread lipolysis in dermal adipocytes.

  • 1/16

    Corticosterone purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Nov 11;8(45):eadd7063. [Abstract]

    Customer Validation
     Corticosterone (CORT) (10 µM, 24 h) is used to produce a cell stress model on the primary culture hippocampal neurons from rats. The decreased NHE1 expression levels in primary cell culture induced by CORT treatment are not affected by chloroquine (Fig. D) but significantly reversed with MG132 pretreatment (Fig. E).

  • 1/16

    Corticosterone purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2022 Jan;25(1):39-49. [Abstract]

    Customer Validation
     Corticosterone (25 mg/kg, drinking water, 21 days) was administered to male and female mice. Fresh corticosterone-containing water was given every other day in the first 2 weeks, and gradually changed to normal water by halving the dose every 2 days in the last week.

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