BAPTA tetracesium
Based on 38 publication(s) in Google Scholar
BAPTA tetracesium is a selective and cell-impermeant chelator for calcium. BAPTA tetracesium has high selectivity against magnesium and calcium. BAPTA tetracesium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
For research use only. We do not sell to patients.
- CAS No.: 480436-84-8
- Formula: C22H20Cs4N2O10
- Molecular Weight:1004.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) BAPTA tetracesium
More- Adv Mater. 2026 Aug;38(47):e74146.
- Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
- Sci Immunol. 2019 Jun 28;4(36):eaau6426. [Abstract]
- J Clin Invest. 2024 Apr 25;134(12):e176355. [Abstract]
- Adv Sci (Weinh). 2021 Aug;8(15):e2100363. [Abstract]
- Environ Chem Ecotoxicol. 2025 Nov 19;8:267-280.
- J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
- Cell Death Discov. 2026 May 25. [Abstract]
- Free Radic Biol Med. 2024 Mar:213:150-163. [Abstract]
- Cell Rep. 2025 Dec 10;44(12):116673. [Abstract]
- J Pineal Res. 2024 Aug;76(5):e12987. [Abstract]
- J Ginseng Res. 2022 Jul;46(4):515-525. [Abstract]
- J Invest Dermatol. 2024 Dec;144(12):2695-2705.e8. [Abstract]
- J Ethnopharmacol. 2025 May 28:348:119863. [Abstract]
- J Ethnopharmacol. 2023 Feb 10;302(Pt A):115923. [Abstract]
- Int J Pharm. 2025 Nov 10:684:126125. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116168. [Abstract]
- Int J Mol Sci. 2026 Jan 1;27(1):468. [Abstract]
- Toxicology. 2023 Dec:500:153674. [Abstract]
- J Thromb Haemost. 2021 Dec;19(12):3113-3125. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jul 18;1871(8):167990. [Abstract]
- Mol Med Rep. 2024 Jan;29(1):13. [Abstract]
- Exp Neurol. 2023 May:363:114350. [Abstract]
- J Cell Mol Med. 2020 Aug;24(16):9287-9299. [Abstract]
- J Funct Foods. 2024 Oct.
- J Funct Foods. December 2021, 104791.
- J Pharm Pharmacol. 2024 May 3;76(5):567-578. [Abstract]
- J Cancer. 2024 Jan 1;15(2):343-355. [Abstract]
- J Pharmacol Sci. 2026 Sep;162(1):50-64.
- Toxicon. 2026 Jun 15:276:109072. [Abstract]
- Cardiovasc Ther. 2023 Mar 30:2023:3939360. [Abstract]
- Vet Microbiol. 2019 Dec:239:108498. [Abstract]
- Res Sq. 2025 Apr 18.
- Biomed Pharmacother. 2023 Oct:166:115343. [Abstract]
- bioRxiv. 2023 Jun 25.
- Biomed Pharmacother. 2023 May:161:114480. [Abstract]
- Sci Total Environ. 2020 Feb 10:703:134702. [Abstract]
- Aging. 2019 Nov 22;11(22):10385-10408. [Abstract]
Customer Validation & Images
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WB
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IF
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RT-PCR
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ELISA
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IF
All Phospholipase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
PLC |
In Vitro
BAPTA tetracesium is widely used as an intracellular buffer to investigate the effects caused by Ca2+ release from intracellular calcium stores or Ca2+ influx via Ca2+-permeable channels in the plasma membrane[1].
BAPTA tetracesium can be introduced into cells via methods such as patch-clamp and microinjection[1].
BAPTA tetracesium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC50 of approximately 8 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 480436-84-8
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Molecular Weight 1004.02
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Formula C22H20Cs4N2O10
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SMILES
O=C(O[Cs])CN(CC(O[Cs])=O)C1=C(OCCOC2=C(N(CC(O[Cs])=O)CC(O[Cs])=O)C=CC=C2)C=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (38)
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Journal Impact Factor
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Most Recent
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Mil Med Res
Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. [Abstract]2023 Nov 25;10(1):56. PMID: 38001521
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.
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Sci Immunol
2019 Jun 28;4(36):eaau6426. PMID: 31253642 -
J Clin Invest
Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. [Abstract]2024 Apr 25;134(12):e176355. PMID: 38662435 -
Adv Sci (Weinh)
2021 Aug;8(15):e2100363. PMID: 34047068 -
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J Neuroinflammation
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage. [Abstract]2025 Aug 28;22(1):208. PMID: 40877894
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.
BAPTA tetracesium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.
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Cell Death Discov
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance. [Abstract]2026 May 25. PMID: 42185253 -
Free Radic Biol Med
Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]2024 Mar:213:150-163. PMID: 38190923 -
Cell Rep
Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation. [Abstract]2025 Dec 10;44(12):116673. PMID: 41385364 -
J Pineal Res
2024 Aug;76(5):e12987. PMID: 38975671 -
J Ginseng Res
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice. [Abstract]2022 Jul;46(4):515-525. PMID: 35818419 -
J Invest Dermatol
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]2024 Dec;144(12):2695-2705.e8. PMID: 38823435 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling. [Abstract]2025 May 28:348:119863. PMID: 40311716 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. [Abstract]2023 Feb 10;302(Pt A):115923. PMID: 36375645 -
Int J Pharm
Reversible increased basement membrane permeability and calcium ion redistribution facilitate ultrasound-enhanced transdermal drug delivery efficiency. [Abstract]2025 Nov 10:684:126125. PMID: 40914558 -
Int Immunopharmacol
Piezo1 activates Wnt5a/FZD4 signaling to promote osteogenesis and mitigates age-associated bone loss. [Abstract]2026 Mar 1:172:116168. PMID: 41529412 -
Int J Mol Sci
Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca2+-CAMKII-ATGL Hepatic Lipolysis. [Abstract]2026 Jan 1;27(1):468. PMID: 41516340 -
Toxicology
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress. [Abstract]2023 Dec:500:153674. PMID: 37989449 -
J Thromb Haemost
2021 Dec;19(12):3113-3125. PMID: 34411418 -
Biochim Biophys Acta Mol Basis Dis
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis. [Abstract]2025 Jul 18;1871(8):167990. PMID: 40684959 -
Mol Med Rep
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice. [Abstract]2024 Jan;29(1):13. PMID: 38038121 -
Exp Neurol
Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. [Abstract]2023 May:363:114350. PMID: 36791875 -
J Cell Mol Med
Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-α-induced autophagy in mouse hippocampal neurons. [Abstract]2020 Aug;24(16):9287-9299. PMID: 32627970 -
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J Pharm Pharmacol
2024 May 3;76(5):567-578. PMID: 38271051 -
J Cancer
JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells. [Abstract]2024 Jan 1;15(2):343-355. PMID: 38169515 -
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Toxicon
Transient receptor potential canonical 6 is critical for chronic lipopolysaccharide exposure-induced pulmonary injury and fibrosis. [Abstract]2026 Jun 15:276:109072. PMID: 41850440 -
Cardiovasc Ther
KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing. [Abstract]2023 Mar 30:2023:3939360. PMID: 37035755 -
Vet Microbiol
S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein. [Abstract]2019 Dec:239:108498. PMID: 31767072 -
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Biomed Pharmacother
Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB. [Abstract]2023 Oct:166:115343. PMID: 37634474 -
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Biomed Pharmacother
Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. [Abstract]2023 May:161:114480. PMID: 37002575 -
Sci Total Environ
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. [Abstract]2020 Feb 10:703:134702. PMID: 31753492 -
Aging
Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans. [Abstract]2019 Nov 22;11(22):10385-10408. PMID: 31757933
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
[1]. Tsien RY, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980;19(11):2396-2404. [Content Brief]
[2]. Hardie RC. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]
[3]. Collatz MB, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium. 1997;21(6):453-459. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BAPTA tetracesium Related Classifications
HY-W778574 Related Classifications
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