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Cat. No.: HY-122064

FR20

FR20 acts as an inhibitor of human microsomal prostaglandin synthase 1 (mPGES 1).

For research use only. We do not sell to patients.

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Please store the product under the recommended conditions in the Certificate of Analysis.

CAS No.: 570373-45-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

FR20 acts as an inhibitor of human microsomal prostaglandin synthase 1 (mPGES 1).

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.13 μM Compound: 7, FR20	Inhibition of mPGES-1 derived from IL1beta and TNFalpha stimulated human HeLa cells microsomal fraction using PGH2 as substrate preincubated for 30 mins prior to substrate addition measured after 1 min by LC-MS/MS analysis Inhibition of mPGES-1 derived from IL1beta and TNFalpha stimulated human HeLa cells microsomal fraction using PGH2 as substrate preincubated for 30 mins prior to substrate addition measured after 1 min by LC-MS/MS analysis	[PMID: 22449023]
HeLa	IC₅₀	0.5 μM Compound: 18	Inhibition of mPGES1 expressed in human HeLa cells assessed as inhibition of IL-1-beta/TNF-alpha-induced PGE2 production by Western blot analysis Inhibition of mPGES1 expressed in human HeLa cells assessed as inhibition of IL-1-beta/TNF-alpha-induced PGE2 production by Western blot analysis	[PMID: 20025212]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

CAS No. 570373-45-4
Molecular Weight 542.46
Formula C₃₁H₂₅Cl₂N₃O₂
SMILES

O=C(C1=CC=CC=C1Cl)NC2=CC3=C(C=C2)N=C(N(C3=O)CC4=CC=C(C=C4)C5=CC=CC(Cl)=C5)CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.