NMB - neuromedin B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4828

About NMB

Cytogenetic location: 15q25.2 Genomic coordinates (GRCh38): 15:84,655,132-84,658,199 (from NCBI)

This gene has 2 transcripts (splice variants), 162 orthologues and 1 paralogue. Biased expression in fat (RPKM 21.3), brain (RPKM 11.2) and 5 other tissues.

Summary

This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

NMB Products (2)

mRNA Protein Name
NM_021077.4 NP_066563.2 neuromedin-B isoform 1 preproprotein
NM_205858.2 NP_995580.1 neuromedin-B isoform 2 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMB Protein Structure

Bombesin

Bombesin: Bombesin-like peptide (47 - 60)

  • 0
  • 100
  • 121 a.a.
Protein Preferred Names Protein Names

neuromedin-B

  • Neuromedin-B-32

NMB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NMB P08949 BIRC2 Homo sapiens Q13490
Validated Y2H
25416956
Intra
NMB P08949 BIRC2 Homo sapiens Q13490
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastrinoma

  • Gastrin Cell Tumour

  • Gastrin Secreting Tumor

  • Malignant Gastrinoma

  • Gastrinoma, Malignant
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Ocular Pigment Dispersion With Or Without Glaucoma

  • Pigment Dispersion Syndrome

  • Glaucoma-Related Pigment Dispersion Syndrome

  • OPDG

  • Pds

  • Glaucoma, Pigment-Dispersion Type

  • Gpds1

  • Pigment-Dispersion Type Glaucoma

  • Pigment-Dispersion Syndrome

  • Glaucoma, Open-Angle
Small Cell Cancer Of The Lung

  • Small Cell Lung Cancer

  • Small Cell Lung Carcinoma

  • Sclc

  • Small-Cell Cancer Of Lung

  • Lung Small Cell Carcinoma

  • Sclc1

  • Sccl

  • Cancer, Lung, Small Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Congenital Central Hypoventilation Syndrome

  • Cchs

  • Haddad Syndrome

  • Ondine Curse

  • Ondine Syndrome

  • Congenital Central Hypoventilation

  • Congenital Central Alveolar Hypoventilation Syndrome

  • Congenital Failure Of Autonomic Control

  • Ondine'S Curse

  • Primary Alveolar Hypoventilation

  • Ondine-Hirschsprung Disease

  • Central Congenital Hypoventilation Syndrome

  • Congenital Ondine Curse

  • Idiopathic Congenital Central Alveolar Hypoventilation

  • Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

  • Ondine-Hirschsprung Syndrome
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-141604 Glembatumumab vedotin Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0241 Neuromedin B 99.22% Unkown
HY-116216 PD 168368 Antagonist ≥99.0% Unkown
HY-N2600 Kuwanon H 98.60% Unkown
HY-103277A BIM 23042 TFA Antagonist 99.75% Unkown
HY-RS05648 GPNMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09368 NMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103277 BIM 23042 Antagonist / Unkown
HY-125075 PD 165929 Antagonist / Unkown
HY-17674 Bombesin receptor antagonist-1 Antagonist / Unkown
HY-N2600R Kuwanon H (Standard) / Unkown
HY-RS17137 Nmb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23583 Nmb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992424 NMB04 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NMB RGD RGD:1562710
Mus musculus NMB MGD MGI:1915289
Bos taurus NMB VGNC VGNC:32123
Canis familiaris NMB VGNC VGNC:43854
Macaca mulatta NMB VGNC VGNC:84410
Felis catus NMB VGNC VGNC:68501
Others NMB NCBI