CD40 - CD40 molecule Gene

Also Known as p50; Bp50; CDW40; TNFRSF5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 958

About CD40

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,118,314-46,129,858 (from NCBI)

This gene has 14 transcripts (splice variants), 127 orthologues, 21 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 19.2), appendix (RPKM 13.7) and 23 other tissues.

Summary

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

CD40 Products (6)

mRNA	Protein	Name
NM_001250.6	NP_001241.1	tumor necrosis factor receptor superfamily member 5 isoform 1 precursor
NM_001302753.2	NP_001289682.1	tumor necrosis factor receptor superfamily member 5 isoform 3 precursor
NM_001322421.2	NP_001309350.1	tumor necrosis factor receptor superfamily member 5 isoform 4 precursor
NM_001322422.2	NP_001309351.1	tumor necrosis factor receptor superfamily member 5 isoform 5 precursor
NM_001362758.2	NP_001349687.1	tumor necrosis factor receptor superfamily member 5 isoform 6 precursor
NM_152854.4	NP_690593.1	tumor necrosis factor receptor superfamily member 5 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	12223522	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7527023	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	38494863	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CD40 signaling pathway	IDA IDA: Inferred from direct assay	8910514	GOA
involved in CD40 signaling pathway	IMP IMP: Inferred from mutant phenotype	21410936	GOA
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	21410936	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	21410936	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	21410936	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	28566713	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	28566713	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21410936	GOA
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	12885753	GOA
involved in positive regulation of interleukin-4-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	12574355	GOA
involved in positive regulation of protein kinase C signaling	IMP IMP: Inferred from mutant phenotype	21410936	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12574355	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21410936	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD40 Protein Structure

TNFR_c6

0
100
200
277 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 5	B cell surface antigen CD40

CD40 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD40	P25942	DEFB121	Homo sapiens	Q5J5C9	Validated Y2H	32296183
Intra	CD40	P25942	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	CD40	P25942	SLC39A13	Homo sapiens	Q96H72	Validated Y2H	32296183
Intra	CD40	P25942	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	CD40	P25942	CMTM6	Homo sapiens	Q9NX76	Anti Tag CoIP	33961781
Intra	CD40	P25942	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	CD40	P25942	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	CD40	P25942	TLCD1	Homo sapiens	Q96CP7	Validated Y2H	32296183
Intra	CD40	P25942	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	CD40	P25942	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	CD40	P25942	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Cross	CD40	P25942	Otud7b	Mus musculus	B2RUR8	Anti Bait CoIP	23334419
Intra	CD40	P25942	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Y2H Bait-Prey Pool	25910212
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	17353931
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	X-Ray Diffraction	10518213
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Pull Down	20676093
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	33961781
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Validated Y2H	25910212
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Y2H Array	25910212
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	CD40	P25942	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	CD40	P25942	TRAF6	Homo sapiens	Q9Y4K3	Pull Down	20676093
Intra	CD40	P25942	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	CD40	P25942	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	CD40	P25942	SLC7A1	Homo sapiens	P30825	Validated Y2H	32296183
Intra	CD40	P25942	MIP	Homo sapiens	P30301	Validated Y2H	32296183
Intra	CD40	P25942	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	CD40	P25942	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD40 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72909	CD40 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P25942-1 (E21-R193)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72910	CD40 Protein, Human (HEK293, Fc)	P25942-1 (E21-R193)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78091	CD40 Protein, Human (Biotinylated, HEK293, His-Avi)	P25942-1 (E21-R193)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P73499A	CD40 Protein, Human (HEK293, His)	P25942-1 (E21-R193)	≥ 95%, as determined by reducing SDS-PAGE.

CD40 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80056	CD40 Antibody (YA805)	WB, ICC/IF, IHC-P	Human
HY-P84215	CD40 Antibody (YA3912)	WB, IHC-P, FC, ELISA	Human
HY-P84215A	CD40 Antibody (YA3912)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85090	CD40 Antibody (YA4782)	ICC/IF, ELISA	Human
HY-P85832	CD40 Antibody (YA5524)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency With Hyper-Igm, Type 3	HIGM3 Immunodeficiency With Hyper Igm Type 3 Hyper-Igm Syndrome Type 3 Hyper-Igm Syndrome 3 Hyper-Igm Syndrome Due To Cd40 Deficiency Cd40 Deficiency Type 3 Hyper-Igm Immunodeficiency Hyper Igm Syndrome 3 Immunodeficiency With Hyper-Igm 3 Hyper-Igm Immunodeficiency Type 3 Immunodeficiency, With Hyper Igm, Type 3 Hyper-Igm Immunodeficiency Syndrome, Type 3
Immunodeficiency With Hyper-Igm, Type 1	Immunodeficiency, X-Linked, With Hyper-Igm Hyper Igm Syndrome HIGM1 Xhim Hyper-Igm Syndrome Higm Hyper-Igm Syndrome 1 Immunodeficiency 3 Imd3 Immunodeficiency With Hyper-Igm Immunodeficiency With Hyper Igm Type 1 Ihis X-Linked Hyper Igm Syndrome Hyper-Igm Immunodeficiency, X-Linked Hyper Igm Immunodeficiency, X-Linked Hyper Igm Syndrome 1 X-Linked Immunodeficiency With Hyper-Igm 1 Immunodeficiency, With Hyper Igm Immunodeficiency, With Hyper Igm, Type 1 Hyper-Igm Immunodeficiency Syndrome, Type 1 Hyperimmunoglobulin M Syndrome
Cd40 Ligand Deficiency	X-Linked Hyper Igm Syndrome Hyperimmunoglobulin M Syndrome Higm1 Hyper-Igm Syndrome Type 1 X-Linked Hyper-Igm Syndrome Xhigm Higmx-1 X-Linked Hyper-Igm Immunodeficiency Hyper-Igm Syndrome 1 Immunodeficiency With Hyper-Igm, Type 1 Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency Hyper-Igm Syndrome Due To Cd40l Deficiency Hyper-Igm Immunodeficiency Syndrome Hyper-Igm Immunodeficiency Syndrome, Type 1
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Light Fixation Seizure Syndrome	M Syndrome Lfss
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton Disease Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
Arteriosclerosis	Arteriosclerotic Vascular Disease
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Pemphigus Foliaceus	Pemphigus Foliaceous Pf Superficial Pemphigus
Kawasaki Disease	Mucocutaneous Lymph Node Syndrome Acute Febrile Mucocutaneous Lymph Node Syndrome Kawasaki Syndrome Kd Infantile Polyarteritis Kawasaki Disease, Susceptibility To Acute Febrile Mcls Kawasaki'S Disease Mlns KWD
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Neuromyelitis Optica	Devic Disease Devic Syndrome Neuromyelitis Optica Spectrum Disorder Devic'S Disease Devic'S Syndrome Devic'S Neuromyelitis Optica Nmo Nmo Spectrum Disorder Neuromyelitis Optica Spectrum Disorders Devic Neuromyelitis Optica Optic-Spinal Ms Opticospinal Ms Nmosd Opticospinal Multiple Sclerosis Devic Ophthalmoneuromyelitis Optic Neuromyelitis Optic Neuroencephalomyelopathy Nmo - [Neuromyelitis Optica] Optic Neuritis With Demyelination
Thyroiditis	Inflammation Of Thyroid Thyroiditis Nos
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Leishmaniasis	Post-Kala-Azar Dermal Leishmaniasis Post Kala-Azar Dermal Leishmaniasis Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis Cutaneous Leishmaniasis Kala-Azar Visceral Leishmaniasis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Leishmania Leishmania Infection Leishmaniosis
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Waldenström Macroglobulinemia Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Immunodeficiency With Hyper-Igm, Type 4	HIGM4 Hyper-Igm Syndrome Type 4 Immunodeficiency With Hyper-Igm Type 4 Hyper-Igm Syndrome 4 Immunodeficiency With Hyper Igm Type 4 Hyper Igm Syndrome 4 Immunodeficiency, With Hyper Igm, Type 4
Leukemia, Acute Monocytic	Acute Monocytic Leukemia Acute Monoblastic Leukemia And Acute Monocytic Leukemia Acute Monocytic Leukaemia Acute Monocytic Leukaemia Without Mention Of Remission Acute Monocytic Leukemia Without Mention Of Remission Acute Monocytic Leukemia, Fab M5 Acute Monocytic Leukemia, Morphology Leukemia, Monocytic, Acute M5b Acute Differentiated Monocytic Leukemia
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Immunodeficiency With Hyper-Igm, Type 2	HIGM2 Hyper-Igm Syndrome Type 2 Hyper-Igm Syndrome 2 Immunodeficiency With Hyper-Igm Type 2 Activation-Induced Cytidine Deaminase Deficiency Aid Deficiency Immunodeficiency With Hyper Igm Type 2 Hyper Igm Syndrome 2 Immunodeficiency With Hyper-Igm 2 Hyper-Igm Immunodeficiency Type 2 Immunodeficiency, With Hyper Igm, Type 2 Hyper-Igm Immunodeficiency Syndrome, Type 2
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Sulfamethoxazole Allergy	Smx Allergy Smz Allergy Sulphamethoxazole Allergy
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Immunodeficiency With Hyper-Igm, Type 5	HIGM5 Hyper-Igm Syndrome 5 Immunodeficiency With Hyper Igm Type 5 Hyper-Igm Syndrome Type 5 Hyper-Igm Syndrome Due To Ung Deficiency Hyper-Igm Syndrome Due To Uracil N-Glycosylase Immunodeficiency With Hyper Igm, Type 5 Hyper Igm Syndrome 5 Immunodeficiency With Hyper-Igm 5 Hyper-Igm Immunodeficiency Type 5 Immunodeficiency, With Hyper Igm, Type 5 Hyper-Igm Immunodeficiency Syndrome, Type 5
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Sjogren Syndrome	Sicca Syndrome Sjogren'S Syndrome Sjögren Syndrome Sjogren-Gougerot Syndrome Keratoconjunctivitis Sicca Sjögren'S Syndrome Xerodermosteosis Dacryosialoadenopathia Atrophicans Gougerot-Houwer-Sjogren Syndrome Gougerot-Sjogren Syndrome Keratoconjunctivitis Sicca-Xerostomia Secreto-Inhibitor-Xerodermostenosis Primary Sjogren Syndrome Primary Sjogren-Gougerot Syndrome Sjogrens Syndrome Primary Sjogrens Syndrome Dry Eye Syndromes
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Psoriasis
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Coccidiosis	Intestinal Coccidiosis Enteric Coccidiosis
Autoimmune Disease Of Endocrine System
Goat Milk Allergy	Capra Hircus Milk Allergy
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Autoimmune Disease Of Exocrine System
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Autoimmune Disease Of Musculoskeletal System
Autoimmune Disease Of Central Nervous System
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Primary Bacterial Infectious Disease
Mature B-Cell Neoplasm	Mature B-Cell Lymphocytic Neoplasm Neoplasm Of Mature B-Cells Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Thyrotoxic Exophthalmos
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Diabetes Mellitus	Diabetes
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9950	Omalizumab	Inhibitor	99.70%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B1618	Corticosterone	Agonist	99.77%	Phase 3
HY-N6664	Gum arabic		/	Phase 3

Inhibitory Antibodies (22)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99625	Frexalimab	Inhibitor	99.00%	Phase 3
HY-P99845	Dazodalibep		99.0%	Phase 3
HY-P99842A	Dapirolizumab	Inhibitor	99.66%	Phase 3
HY-P99046	Selicrelumab	Agonist	99.29%	Phase 2
HY-P99315	Ruplizumab	Inhibitor	99.84%	Phase 2
HY-P99742	Mitazalimab	Inhibitor	99.23%	Phase 2
HY-P99670	Iscalimab	Inhibitor	99.64%	Phase 2
HY-P99049	Sotigalimab	Agonist	98.90%	Phase 2
HY-P990726	Abiprubart		99.00%	Phase 2
HY-P99257	Bleselumab	Inhibitor	98.97%	Phase 2
HY-P99701	Letolizumab	Inhibitor	98.32%	Phase 2
HY-P99167	Lucatumumab	Inhibitor	≥99.0%	Phase 2
HY-P99015	Dacetuzumab	Inhibitor	95.37%	Phase 2
HY-P99821	Ravagalimab	Inhibitor	99.31%	Phase 2
HY-P99572	Tecaginlimab	Inhibitor	99.00%	Phase 2
HY-P991525	2141-V11	Agonist	98.00%	Phase 2
HY-P991510	CDX-1140	Agonist	/	Phase 2
HY-P991554	FFP-104	Modulator	/	Phase 2
HY-P991556	TQB2916	Agonist	/	Phase 2
HY-P991921	TNX-1500	Inhibitor	/	Phase 2
HY-P99325	Toralizumab	Inhibitor	99.57%	Phase 1
HY-P991666	BMS-986090	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122663A	BIO8898	Inhibitor	98.77%	Unkown
HY-120323	DRI-C21045	Inhibitor	98.11%	Unkown
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	Unkown
HY-148980A	Polyinosinic acid sodium		91.5%	Unkown
HY-154821A	DRI-C21041 DIEA	Inhibitor	99.07%	Unkown
HY-131968	BMS-986202	Inhibitor	99.29%	Unkown
HY-153345	Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br	Agonist	99.67%	Unkown
HY-49382	Fluocinolone acetonide 3-benzylaniline		99.93%	Unkown
HY-154822	DRI-C25441	Inhibitor	99.53%	Unkown
HY-118922	IW927	Inhibitor	99.23%	Unkown
HY-152121	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	Agonist	95.68%	Unkown
HY-122663	(Rac)-BIO8898	Inhibitor	98.03%	Unkown
HY-16668	Tyrphostin A1	Inhibitor	98.96%	Unkown
HY-125025	SMI 6860766	Inhibitor	/	Unkown
HY-154821	DRI-C21041	Inhibitor	/	Unkown
HY-D1236	Fluorescent brightener 71	Inhibitor	/	Unkown
HY-P10399	KGYY15	Inhibitor	99.19%	Unkown
HY-148980	Polyinosinic acid		/	Unkown
HY-143410	Anti-inflammatory agent 16	Inhibitor	/	Unkown
HY-148459	ATAC21		/	Unkown
HY-171590	SIK2-IN-3	Inhibitor	/	Unkown
HY-179701	NIK-IN-3	Inhibitor	/	Unkown
HY-D1124	Mordant brown 1		/	Unkown
HY-D3334	PE-CF594		/	Unkown
HY-P10937	AQP4 (205-215)		/	Unkown
HY-P10937A	AQP4 (205-215) TFA		/	Unkown
HY-RS02246	CD40 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02247	CD40LG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120471	AM-0687	Inhibitor	/	Unkown
HY-168384	M04		/	Unkown
HY-174737	Human CD40LG mRNA		/	Unkown
HY-174738	Human CD40 mRNA		/	Unkown
HY-400878	Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal	Agonist	99.86%	Unkown
HY-RS16527	Cd40 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17669	Cd40lg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22958	Cd40 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24130	Cd40lg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990680	Anti-Mouse CD40 Antibody (FGK4.5/FGK45)	Inhibitor	98.35%	Unkown
HY-P990083	Tegoprubart	Inhibitor	99.86%	Unkown
HY-P990134	Anti-Mouse CD40L/CD154 Antibody (MR-1)	Inhibitor	99.62%	Unkown
HY-P990860	Anti-CD40 Antibody (G28.5)	Inhibitor	95.00%	Unkown
HY-P990133	Anti-Monkey/Human CD40L/CD154 Antibody (5C8)	Inhibitor	95.00%	Unkown
HY-P990111	BMS-986325 (anti-CD40)	Inhibitor	99.84%	Unkown
HY-P991513	BI-655064	Inhibitor	98.56%	Unkown
HY-P99321	Teneliximab	Inhibitor	≥99.0%	Unkown
HY-P991126	Ciltistotug	Ligand	95.376%	Unkown
HY-P99663	Inezetamab	Inhibitor	99.77%	Unkown
HY-P990269	Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1)	Inhibitor	95.00%	Unkown
HY-P991086	MGD010	Inhibitor	99.06%	Unkown
HY-P990270	Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1)		/	Unkown
HY-P991460	Sym029	Agonist	/	Unkown
HY-P991555	XmAb5485	Inducer	/	Unkown
HY-P991557	ABI793	Inhibitor	/	Unkown
HY-P991918	KHK2840	Agonist	/	Unkown
HY-P991919	SBT-040		/	Unkown
HY-P992408	MEDI-5083		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD40	VGNC	VGNC:70703
Bos taurus	CD40	VGNC	VGNC:27033
Rattus norvegicus	CD40	RGD	RGD:619830
Felis catus	CD40	VGNC	VGNC:60627
Canis familiaris	CD40	VGNC	VGNC:38958
Mus musculus	CD40	MGD	MGI:88336
Others	CD40	NCBI