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Referencia número: HY-N21794

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Dendrobine-N-oxide

Dendrobine-N-oxide is a dendrobine-type sesquiterpene alkaloid. It is isolated from Dendrobium nobile. Dendrobine-N-oxide inhibits neuroinflammation, reduces β-Amyloid accumulation, enhances the expression of neurotrophic factors, suppresses the hyperphosphorylation of Tau protein, and exerts anti-neuronal Apoptosis effects. Dendrobine-N-oxide shows no anticancer activity against colon cancer and pancreatic adenocarcinoma. It is used in research on neurodegenerative diseases.

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No. CAS: 40072-57-9
Fòrmula: C₁₆H₂₅NO₃
Peso molecular:279.37

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (296 KB)

Dendrobine-N-oxide Chemical Structure

No. CAS: 40072-57-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC50	>50 μM	Cytotoxicity against human HCT-116 colon tumour cells measured by MTT assay. Cytotoxicity against human HCT-116 colon tumour cells measured by MTT assay.	34930072
SW1990	IC50	>50 μM	Cytotoxicity against human SW1990 pancreatic tumour cells measured by MTT assay. Cytotoxicity against human SW1990 pancreatic tumour cells measured by MTT assay.	34930072

In Vitro

Anti-cancer

Dendrobine-N-oxide (up to 50 μM) exhibits no cytotoxic activity against human HCT-116 and SW1990 cell lines, with IC₅₀ values exceeding 50 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

No. CAS 40072-57-9
Peso molecular 279.37
Fòrmula C₁₆H₂₅NO₃
SMILES

C[C@@]12[C@@]3([H])[C@@]4([H])[C@H]([C@@](C(O4)=O)([H])[C@]1([H])CC[C@]2([H])C[N+]3([O-])C)C(C)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (296 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang C, et al. Research Progress on the Alkaloids of Dendrobium nobile: Substantiation, Key Components, Pharmacological Activity, and Biosynthetic Pathways. Curr Issues Mol Biol. 2026 May 29;48(6):570.

[2]. Liu Q, et al. Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI. Front Plant Sci. 2023 Jan 12;13:1125872.

[3]. Zhang MS, et al. Dendrobine-type alkaloids from Dendrobium nobile. Nat Prod Res. 2022 Nov;36(21):5393-5399.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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Dendrobine-N-oxide