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Referencia número: HY-181790

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DOT1L ligand-2

DOT1L ligand-2 (Compound 52) is a DOT1L ligand. DOT1L ligand-2 acts as a Ligand for Target Protein for PROTAC, which is used to develop and design degraders of PROTAC DOT1L, such as DOT1L808 (HY-181789). DOT1L ligand-2 is applicable to research related to MLL-rearranged leukemia.

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Fòrmula: C₂₃H₁₆Cl₂F₂N₆O₄S
Peso molecular:581.38

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOT1L ligand-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
Chemical Information
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IC₅₀ & Target

^[1]

DOT1L

Ver todos los productos específicos de isoformas Histone Methyltransferase :

Chemical Information

Peso molecular 581.38
Fòrmula C₂₃H₁₆Cl₂F₂N₆O₄S
SMILES

FC(F)(OC1=CC=C2)OC1=C2[C@@H](C3=C(C=CC=N3)Cl)NC(C=CC(S(C)(=O)=O)=C4)=C4NC5=NC(Cl)=NC=N5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Quan S, et al. Development of DOT1L-Targeted Protein Degraders for Treating MLL-r Leukemia. J Med Chem. 2026;69(4):4439-4468. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
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DOT1L ligand-2

Ver todos los productos específicos de isoformas Histone Methyltransferase

Actividad biológica

Descripciòn

IC50 & Target

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

DOT1L ligand-2 Related Classifications

HY-181790 Related Classifications

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