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Referencia número: HY-N3209

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Nelumol A

Nelumol A is a farnesoid X receptor (FXR) agonist.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 77836-86-3
Fòrmula: C₂₁H₃₀O₄
Peso molecular:346.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Nelumol A Chemical Structure

No. CAS: 77836-86-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Nelumol A is a farnesoid X receptor (FXR) agonist^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.4 x 10^-5 M Compound: 6	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 12088436]
A549	IC₅₀	76 μM Compound: 36	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21696954]
HL-60	IC₅₀	6.7 μM Compound: 6	Cytotoxicity against human HL60 cells by SRB assay Cytotoxicity against human HL60 cells by SRB assay	[PMID: 12088436]
HL-60	IC₅₀	6.7 x 10^-6 M Compound: 6	Cytotoxicity against human HL60 cells by SRB assay Cytotoxicity against human HL60 cells by SRB assay	[PMID: 12088436]
KB	IC₅₀	3 μM Compound: 6	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 12088436]
KB	IC₅₀	3 x 10^-6 M Compound: 6	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 12088436]
LoVo	IC₅₀	38 μM Compound: 36	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 21696954]
PC-3	IC₅₀	40 μM Compound: 36	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21696954]
SK-MEL-28	IC₅₀	72 μM Compound: 36	Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 21696954]
U-373MG ATCC	IC₅₀	42 μM Compound: 36	Cytotoxicity against human U373 cells after 72 hrs by MTT assay Cytotoxicity against human U373 cells after 72 hrs by MTT assay	[PMID: 21696954]

Chemical Information

No. CAS 77836-86-3
Peso molecular 346.46
Fòrmula C₂₁H₃₀O₄
SMILES

C/C(C)=C/CC/C(C)=C/COC1=C(C=C(/C=C/CO)C=C1OC)OC
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- Compositae
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Francesco Epifano, et al. Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist. Bioorg Med Chem Lett. 2012 May 1;22(9):3130-5. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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