P-CAB agent 1
P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs).
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- No. CAS: 2374139-68-9
- Fòrmula: C26H23FN4O
- Peso molecular:426.49
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 60.50 nM (H+/K+-ATPase)[1]
Pharmacokinetic Parameters of P-CAB agent 1 in female Sprague-Dawley rats[1].
| IV (2 mg/kg) | PO (8 mg/kg) | |
| AUC0-∞ (ug/L*hr) | 519.57 | 341.49 |
| t1/2 (ng/mL) | 0.49 | 0.8 |
| Cmax (ug/L) | 149.93 | 17 |
| F (%) | 16.43 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2374139-68-9
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Peso molecular 426.49
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Fòrmula C26H23FN4O
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SMILES
O=C(N)C1=CC(C2=CC=CC(CN3N=C4CN(CC4=C3C5=CC=CC=C5F)C)=C2)=CC=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P-CAB agent 1 Related Classifications
HY-150555 Related Classifications
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