Exatecan Intermediate 4 dihydrochloride
Based on 1 Customer Validation
Exatecan Intermediate 4 dihydrochloride (Compound 14f) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers.
For research use only. We do not sell to patients.
- Purity: 99.92%
- Formula: C11H15Cl2FN2O
- Molecular Weight:281.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Camptothecins |
can be used in the preparation of antibody-drug conjugates. Camptothecin derivatives generally exhibit antitumor effects by inhibiting topoisomerase I[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 281.15
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Formula C11H15Cl2FN2O
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Color Brown to breen
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SMILES
[H]Cl.[H]Cl.CC1=C2CCC(C(C2=C(C=C1F)N)=O)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (71.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.5568 mL | 17.7841 mL | 35.5682 mL | 88.9205 mL |
| 5 mM | 0.7114 mL | 3.5568 mL | 7.1136 mL | 17.7841 mL | |
| 10 mM | 0.3557 mL | 1.7784 mL | 3.5568 mL | 8.8921 mL | |
| 15 mM | 0.2371 mL | 1.1856 mL | 2.3712 mL | 5.9280 mL | |
| 20 mM | 0.1778 mL | 0.8892 mL | 1.7784 mL | 4.4460 mL | |
| 25 mM | 0.1423 mL | 0.7114 mL | 1.4227 mL | 3.5568 mL | |
| 30 mM | 0.1186 mL | 0.5928 mL | 1.1856 mL | 2.9640 mL | |
| 40 mM | 0.0889 mL | 0.4446 mL | 0.8892 mL | 2.2230 mL | |
| 50 mM | 0.0711 mL | 0.3557 mL | 0.7114 mL | 1.7784 mL | |
| 60 mM | 0.0593 mL | 0.2964 mL | 0.5928 mL | 1.4820 mL |
Exatecan Intermediate 4 dihydrochloride Related Classifications
HY-W021377C Related Classifications
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