2. Epigenetics
  3. Histone Methyltransferase
  4. EZH2-IN-13

EZH2-IN-13 is a potent EZH2 inhibitor, for details please refer to compound 73 in patent WO2017139404. EZH2-IN-13 can be used to study cancers or precancerous lesions associated with EZH2 activity.

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EZH2-IN-13

EZH2-IN-13 화학구조

CAS No. : 1403255-41-3

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

EZH2-IN-13 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

EZH2-IN-13 is a potent EZH2 inhibitor, for details please refer to compound 73 in patent WO2017139404. EZH2-IN-13 can be used to study cancers or precancerous lesions associated with EZH2 activity[1].

IC50 & Target

EZH2

 

분자량

571.75

화학식

C34H45N5O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC(C2=CC=C(CN3CCNCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(C)C=C(C)NC5=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 125 mg/mL (218.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7490 mL 8.7451 mL 17.4902 mL
5 mM 0.3498 mL 1.7490 mL 3.4980 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.72%

SDS (251 KB)

COA (252 KB) HNMR (220 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7490 mL 8.7451 mL 17.4902 mL 43.7254 mL
5 mM 0.3498 mL 1.7490 mL 3.4980 mL 8.7451 mL
10 mM 0.1749 mL 0.8745 mL 1.7490 mL 4.3725 mL
15 mM 0.1166 mL 0.5830 mL 1.1660 mL 2.9150 mL
20 mM 0.0875 mL 0.4373 mL 0.8745 mL 2.1863 mL
25 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7490 mL
30 mM 0.0583 mL 0.2915 mL 0.5830 mL 1.4575 mL
40 mM 0.0437 mL 0.2186 mL 0.4373 mL 1.0931 mL
50 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8745 mL
60 mM 0.0292 mL 0.1458 mL 0.2915 mL 0.7288 mL
80 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5466 mL
100 mM 0.0175 mL 0.0875 mL 0.1749 mL 0.4373 mL
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EZH2-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EZH2-IN-131403255-41-3Histone MethyltransferaseEZH2histone methyltransferasecancerInhibitorinhibitorinhibit

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Inquiry Information

상품명:
EZH2-IN-13
Cat. No.:
HY-147230
수량:
MCE Japan Authorized Agent:

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비고

SAFETY DATA SHEET (SDS)

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