2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3-IN-22

FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L.

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FLT3-IN-22 Chemical Structure

FLT3-IN-22 Chemical Structure

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FLT3-IN-22 Related Antibodies

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Description

FLT3-IN-22 (compound 22f) is a potent FLT3 inhibitor with IC50 values of 0.941 nM and 0.199 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-22 exhibits strong antiproliferative activity against MV4-11 cells and the mutant FLT kinase expressed Ba/F3 cell lines, including FLT-D835Y and FLT3-F691L[1].

IC50 & Target

IC50: 0.941 nM (FLT3) and 0.199 nM (FLT3/D835Y)[1]
Molecular Weight

426.47

Formula

C24H22N6O2
SMILES

O=C(N[C@H]1CC[C@H](N)C1)C2=CC=C(NN=C3C4=NC5=C(C=C(C6=COC=C6)C=C5)N4)C3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLT3-IN-22 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-22FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3FLT3 inhibitorFLT3/D835YFLT3-F691Lanticancer effectInhibitorinhibitorinhibit

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