FLT3/ITD-IN-1
FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 38.2 nM and 144.1 nM against FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-1 displays excellent antiproliferative activities against acute myeloid leukemia cell lines.
For research use only. We do not sell to patients.
- Formula: C19H22N6O2
- Molecular Weight:366.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 38.2 nM (FLT3), 144.1 nM (FLT3-ITD)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
19.4 nM
Compound: 1
|
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
|
[PMID: 34583130] |
| MV4-11 | IC50 |
5.3 nM
Compound: 1
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
|
[PMID: 34583130] |
Chemical Information
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Molecular Weight 366.42
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Formula C19H22N6O2
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SMILES
COC1=CC=CC=C1NC(C2=C3N=C(C=CN3N=C2)N[C@@H]4CCCNC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)