ONO4057
Based on 1 Customer Validation
ONO4057 is a Leukotriene B4 receptor antagonist, with an IC50 of 0.7±0.3 μM.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 134578-96-4
- Formula: C27H34O7
- Molecular Weight:470.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- Purity & Documentation
- References
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Help & FAQs
All Leukotriene Receptor Isoforms
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Biological Activity
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LTB4 0.7 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 134578-96-4
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Appearance Solid
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Molecular Weight 470.55
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Formula C27H34O7
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Color White to off-white
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SMILES
O=C(O)CCC1=C(OCCCC/C=C/C2=CC=C(OC)C=C2)C=CC=C1OCCCCC(O)=O
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Synonyms
ONO-LB457
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocol
Inbred male ACI (180 to 210 g) and LEW (200 to 240 g) rats are used as donors and recipients. Liver transplantation is orthotopically performed. ONO4057 dissolved in 7% NaHCO3 or solvent is administered subcutaneously daily after transplantation. Animals are divided into two groups: group I (n=5), 7% NaHCO3 3 mL/kg as controls; group II (n=6), ONO4057 30 mg/kg per day[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Kishikawa K, et al. ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. [Content Brief]
[2]. Tanaka M, et al. Effect of leukotriene B(4) receptor antagonist (ONO4057) on hepatic allografting in rats. Transplant Proc. 2000 Nov;32(7):2340. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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