TG 41
TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes.
For research use only. We do not sell to patients.
- CAS No.: 850339-33-2
- Formula: C18H13BrCl2N2O2
- Molecular Weight:440.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
0.19 μM
Compound: 1n
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Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes
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[PMID: 15801854] |
TG41 (0.001-10 µM) increases specific [3H]GABA binding to rat cerebral cortical membranes[1].
TG41 (0.001-10 µM) increases inward Cl- currents in X. laevis oocytes expressing recombinant α1β2γ2L GABAA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:5 mg/kg
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Administration:i.v.
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Result:Induced loss of the righting reflex within 8 s and for a duration of 28 min.
Chemical Information
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CAS No. 850339-33-2
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Molecular Weight 440.12
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Formula C18H13BrCl2N2O2
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SMILES
O=C(C1=CN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(Br)C=C3)=N1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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