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Cat. No.: HY-185977

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a12Dab4

a12Dab4 is a peptide ionizable lipid (PIL) used in lipid nanoparticle (LNP) formulations for targeted delivery of mRNA to the liver.

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CAS No.: 3113145-01-7
Formule: C₁₁₄H₂₂₉N₉O₅
Masse moléculaire:1806.10

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

a12Dab4 Chemical Structure

CAS No.: 3113145-01-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

a12Dab4 is a peptide ionizable lipid (PIL) used in lipid nanoparticle (LNP) formulations for targeted delivery of mRNA to the liver^[1].

In Vivo

a12Dab4 enables organ-specific prime editing in mouse liver through co-delivery of PEmax mRNA and engineered prime editing guide RNAs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3113145-01-7
Masse moléculaire 1806.10
Formule C₁₁₄H₂₂₉N₉O₅
SMILES

CC(N[C@H](C(N[C@@H](CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N[C@@H](CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N[C@@H](CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)C(N)=O)=O)=O)=O)CCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lin Y, et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nature materials. 2026 Jan;25(1):133-145. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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