AM31
AM31 is a PGC-1α1 stabilizer. AM31 enhances the protein stability of PGC-1α1, promotes protein accumulation and target gene activation. AM31 induces the expression of Ucp1 and Cidea in brown adipocytes. AM31 increases the levels of basal mitochondrial respiration and uncoupled respiration in brown adipocytes. AM31 can be used for the research of obesity and related metabolic disorders.
For research use only. We do not sell to patients.
- Formula: C17H12F3N5O
- Molecular Weight:359.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AM31 (10 μM; 8 h) stabilizes the EGFP-PGC-1α1 fusion protein in HEK 293-EGFPmPGC-1α1 cells[1].
AM31 (10 μM; 8 h) activates the expression of PGC-1α target genes in fully differentiated immortalized mouse brown adipocytes[1].
AM31 (10 μM; 8 h) stabilizes endogenous PGC-1α protein in fully differentiated immortalized mouse brown adipocytes following treatment with 10 μM for 8 h[1].
AM31 (10 μM; 8 h) increases basal mitochondrial respiration and uncoupled mitochondrial respiration levels in fully differentiated immortalized mouse brown adipocytes treated with 10 μM for 8 h, with the uncoupled respiration elevated by up to 38%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:fully differentiated mouse immortalized brown adipocytes
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Concentration:10 μM
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Incubation Time:8 h
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Result:Induced a 12-fold increase in Ucp1 gene expression relative to DMSO control.
Induced a 4-fold increase in Cidea gene expression relative to DMSO control.
Induced smaller increases in expression of other PGC-1α target genes including Tra2, Fsp27, Cytc, Tfam, Cpt1b, Esrra, Prdm16, Pparg, and Sod1 relative to DMSO control.
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Cell Line:fully differentiated mouse immortalized brown adipocytes
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Concentration:10 μM
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Incubation Time:8 h
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Result:Induced accumulation of endogenous PGC-1α protein, with levels comparable to those induced by isoproterenol treatment and lower than MG132-induced levels.
Chemical Information
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Molecular Weight 359.31
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Formula C17H12F3N5O
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SMILES
O=C1C2C(N(C3=CC(C(F)(F)F)=CC=C3)N=C2)N=C(C4=CC=CC=N4)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM31 Related Classifications
HY-183096 Related Classifications
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