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Cat. No.: HY-106155

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Amdoxovir

(Synonyms: DAPD)

Amdoxovir (DAPD) is an orally active nucleoside reverse transcriptase inhibitor. Amdoxovir is active against wild-type and NRTl-resistant viruses. Amdoxovir is the prodrug of dioxolane guanosine. Amdoxovir can be used for research of HIV/AIDS.

For research use only. We do not sell to patients.

CAS No.: 145514-04-1
Formula: C₉H₁₂N₆O₃
Molecular Weight:252.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Amdoxovir Chemical Structure

CAS No.: 145514-04-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	CC₅₀	>100 μM Compound: DAPD, AMDX	Cytotoxicity against human CEM cells after 2 to 4 days by MTT assay Cytotoxicity against human CEM cells after 2 to 4 days by MTT assay	[PMID: 24015326]
CCRF-CEM	CC₅₀	>100 μM Compound: 1, DAPD	Cytotoxicity against human CEM cell Cytotoxicity against human CEM cell	[PMID: 25458500]
HepG2	CC₅₀	>100 μM Compound: DAPD, AMDX	Cytotoxicity against human HepG2 cells after 2 to 4 days by neutral red dye uptake assay Cytotoxicity against human HepG2 cells after 2 to 4 days by neutral red dye uptake assay	[PMID: 24015326]
HepG2	CC₅₀	>100 μM Compound: 1, DAPD	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 25458500]
Huh-7	CC₅₀	>100 μM Compound: DAPD, AMDX	Cytotoxicity against human HuH7 cells after 2 to 4 days by MTT assay Cytotoxicity against human HuH7 cells after 2 to 4 days by MTT assay	[PMID: 24015326]
PBMC	CC₅₀	>100 μM Compound: DAPD, AMDX	Cytotoxicity against human PBMC after 2 to 4 days by MTT assay Cytotoxicity against human PBMC after 2 to 4 days by MTT assay	[PMID: 24015326]
PBMC	CC₅₀	>100 μM Compound: 1, DAPD	Cytotoxicity against human PBMC Cytotoxicity against human PBMC	[PMID: 25458500]
Vero	CC₅₀	>100 μM Compound: DAPD, AMDX	Cytotoxicity against African green monkey Vero cells after 2 to 4 days by MTT assay Cytotoxicity against African green monkey Vero cells after 2 to 4 days by MTT assay	[PMID: 24015326]
Vero	CC₅₀	>100 μM Compound: 1, DAPD	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 25458500]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 145514-04-1
Molecular Weight 252.23
Formula C₉H₁₂N₆O₃
SMILES

NC1=C2C(N([C@@H]3O[C@@H](OC3)CO)C=N2)=NC(N)=N1
Synonyms

DAPD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gripshover BM, et al. Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118). Antivir Ther. 2006;11(5):619-23. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Amdoxovir

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Amdoxovir Related Classifications

HY-106155 Related Classifications