PEG500
Based on 1 Customer Validation
PEG500 (Polyethylene glycol 500) is a versatile polymer that's used as a solvent, dispersant, lubricant, and more in industries like pharmaceuticals and biotechnology, and it can also modify liposomes. PEG500 is commonly used as a solvent or carrier for drugs, helping with capsule endoscopy to improve image quality and cecum completion rates.
For research use only. We do not sell to patients.
- CAS No.: 25322-68-3
- Formula: (C2H4O)nH2O
- Molecular Weight:500.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
The FDA has approved polyethylene glycol (PEG) for use as a vehicle or base in foods, cosmetics and pharmaceuticals, including injectable, topical, rectal and nasal formulations. PEG shows little toxicity, and is eliminated from the body intact by either the kidneys (for PEGs < 30 kDa) or in the faeces (for PEGs > 20 kDa). PEG lacks immunogenicity, and antibodies to PEG are generated in rabbits only if PEG is combined with highly immunogenic proteins[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25322-68-3
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Appearance Solid-Liquid Mixture
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Molecular Weight 500.00
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Formula (C2H4O)nH2O
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Color Colorless to off-white
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SMILES
[H]OCCO[H].[n]
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Synonyms
Polyethylene glycol 500
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : 100 mg/mL (200.00 mM; Need ultrasonic)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Endo H, et al. Ingesting 500 ml of polyethylene glycol solution during capsule endoscopy improves the image quality and completion rate to the cecum. Dig Dis Sci. 2008 Dec;53(12):3201-5. [Content Brief]
[2]. Yasuyuki Sadzuka, et al. Effects of mixed polyethyleneglycol modification on fixed aqueous layer thickness and antitumor activity of doxorubicin containing liposome. Int J Pharm. 2002 May 15;238(1-2):171-80. [Content Brief]
[3]. Harris JM, et al. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003 Mar;2(3):214-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0000 mL | 10.0000 mL | 20.0000 mL | 50.0000 mL |
| 5 mM | 0.4000 mL | 2.0000 mL | 4.0000 mL | 10.0000 mL | |
| 10 mM | 0.2000 mL | 1.0000 mL | 2.0000 mL | 5.0000 mL | |
| 15 mM | 0.1333 mL | 0.6667 mL | 1.3333 mL | 3.3333 mL | |
| 20 mM | 0.1000 mL | 0.5000 mL | 1.0000 mL | 2.5000 mL | |
| 25 mM | 0.0800 mL | 0.4000 mL | 0.8000 mL | 2.0000 mL | |
| 30 mM | 0.0667 mL | 0.3333 mL | 0.6667 mL | 1.6667 mL | |
| 40 mM | 0.0500 mL | 0.2500 mL | 0.5000 mL | 1.2500 mL | |
| 50 mM | 0.0400 mL | 0.2000 mL | 0.4000 mL | 1.0000 mL | |
| 60 mM | 0.0333 mL | 0.1667 mL | 0.3333 mL | 0.8333 mL | |
| 80 mM | 0.0250 mL | 0.1250 mL | 0.2500 mL | 0.6250 mL | |
| 100 mM | 0.0200 mL | 0.1000 mL | 0.2000 mL | 0.5000 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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