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Cat. No.: HY-173573

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TK-684

TK-684 is a potent and selective allosteric SHP2 inhibitor with IC₅₀ values of 2.1, ＞1000 nM for SHP2^WT, SHP22^PTP, respectively. TK-684 inhibits cell proliferation and induces apoptosis. TK-684 decreases the protein expression of p-AKT, p-ERK.

For research use only. We do not sell to patients.

Formula: C₁₇H₂₁ClN₈OS
Molecular Weight:420.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TK-684 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

TK-684 (1.25-100 μM; 72 h) inhibits cell proliferative in KYSE-150 cells^[1].
TK-684 (0-40 μM; 48 h) induces apoptosis^[1].
TK-684 (0-20 μM; 2 h) decreases the protein expression of p-AKT, p-ERK in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

KYSE-150 cells
Concentration:

1.25-100 μM
Incubation Time:

72 h
Result:

Inhibited cell proliferative.

Apoptosis Analysis^[1]

Cell Line:

KYSE-150 cells
Concentration:

0-40 μM
Incubation Time:

48 h
Result:

Induced cell apoptosis.

Western Blot Analysis^[1]

Cell Line:

KYSE-150 cells
Concentration:

0-20 μM
Incubation Time:

2 h
Result:

Decreased the protein expression of p-AKT, p-ERK in a dose-dependent manner.

Parmacokinetics

Species	Dose	Route	T_1/2	Bioavailability
Rat	10 mg/kg	p.o.	2.41 h	0.9 %

Chemical Information

Molecular Weight 420.92
Formula C₁₇H₂₁ClN₈OS
SMILES

ClC1=C(N=CC=C1SC2=NNC(N=C(N3)N4CCC(C)(CC4)CN)=C2C3=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song Y, et al. Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors. J Med Chem. 2025 Apr 16. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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