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Referencia número: HY-18604

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K-Ras G12C-IN-1

1 Cited Publications

Revisión del cliente

Based on 1 publication(s) in Google Scholar

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.19%
No. CAS: 1629265-17-3
Fòrmula: C₂₂H₂₃Cl₂N₃O₃
Peso molecular:448.34

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

K-Ras G12C-IN-1 Chemical Structure

No. CAS: 1629265-17-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. IC50 value: Target: K-ras G12C inhibitor

Ver todos los productos específicos de isoformas Ras :

Chemical Information

No. CAS 1629265-17-3
Appearance Solid
Peso molecular 448.34
Fòrmula C₂₂H₂₃Cl₂N₃O₃
Color White to off-white
SMILES

ClC(C=C(OC)C(NCC(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC=CC=C3Cl
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Cell Chem Biol

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS. [Abstract]

2026 Feb 11:S2451-9456(26)00027-9. PMID: 41679298

Solvente y solubilidad

In Vitro:

DMSO : ≥ 40 mg/mL (89.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2305 mL

11.1523 mL

22.3045 mL

5 mM

0.4461 mL

2.2305 mL

4.4609 mL

10 mM

0.2230 mL

1.1152 mL

2.2305 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (242 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2305 mL	11.1523 mL	22.3045 mL	55.7613 mL
	5 mM	0.4461 mL	2.2305 mL	4.4609 mL	11.1523 mL
	10 mM	0.2230 mL	1.1152 mL	2.2305 mL	5.5761 mL
	15 mM	0.1487 mL	0.7435 mL	1.4870 mL	3.7174 mL
	20 mM	0.1115 mL	0.5576 mL	1.1152 mL	2.7881 mL
	25 mM	0.0892 mL	0.4461 mL	0.8922 mL	2.2305 mL
	30 mM	0.0743 mL	0.3717 mL	0.7435 mL	1.8587 mL
	40 mM	0.0558 mL	0.2788 mL	0.5576 mL	1.3940 mL
	50 mM	0.0446 mL	0.2230 mL	0.4461 mL	1.1152 mL
	60 mM	0.0372 mL	0.1859 mL	0.3717 mL	0.9294 mL
	80 mM	0.0279 mL	0.1394 mL	0.2788 mL	0.6970 mL

Keywords

K-Ras G12C-IN-1

1 Cited Publications

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Actividad biológica
- Descripciòn
Chemical Information
Publications (1)
Solvente y solubilidad
- In Vitro
Pureza y Documentación

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K-Ras G12C-IN-1

Covalent Screening Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Publications Citing Use of MedChemExpress (MCE) K-Ras G12C-IN-1

Ver todos los productos específicos de isoformas Ras

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Help & FAQs

Complete Stock Solution Preparation Table

K-Ras G12C-IN-1

Covalent Screening Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glutamine Metabolism Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Anti-Cancer Compound Library

Publications Citing Use of MedChemExpress (MCE) K-Ras G12C-IN-1

Ver todos los productos específicos de isoformas Ras

Actividad biológica

Chemical Information

Publications (1)

Solvente y solubilidad

Pureza y Documentación

Help & FAQs

Complete Stock Solution Preparation Table

K-Ras G12C-IN-1 Related Classifications

HY-18604 Related Classifications