Org41841
Based on 1 Customer Validation
Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.
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- Pureza: 99.77%
- No. CAS: 301847-37-0
- Fòrmula: C19H22N4O2S2
- Peso molecular:402.53
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
EC50: 0.2 μM (LHCGR), 7.7 μM (TSHR)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.3 μM
Compound: 3,Org 41841
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Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
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[PMID: 16789744] |
| HEK293 | EC50 |
6.5 μM
Compound: 3,Org 41841
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Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
Agonist activity at TSHR expressed in HEK293 EM cells measured by intracellular cAMP accumulation
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[PMID: 16789744] |
Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 301847-37-0
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Appearance Solid
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Peso molecular 402.53
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Fòrmula C19H22N4O2S2
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Color White to yellow
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SMILES
O=C(C1=C(N)C2=C(C3=CC=CC(OC)=C3)N=C(SC)N=C2S1)NC(C)(C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (248.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocolo
Transfected cells are cultured for 48 h before incubation for 1 h in serum-free Dulbecco's modified Eagle's medium containing 1 mM 3-isobutyl-1-methylxanthine and bovine thyroid-stimulating hormone (TSH) (0 to 1.8 μM) or human LH (0.1 to 1000 ng) or Org41841 (0 to100 μM) in a humidified 5% CO2 incubator. Following aspiration of the medium, cells are lysed using lysis buffer 1 of the cAMP Biotrak Enzymeimmunoassay System. The cAMP content of the cell lysate is determined and data are analyzed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4843 mL | 12.4214 mL | 24.8429 mL | 62.1072 mL |
| 5 mM | 0.4969 mL | 2.4843 mL | 4.9686 mL | 12.4214 mL | |
| 10 mM | 0.2484 mL | 1.2421 mL | 2.4843 mL | 6.2107 mL | |
| 15 mM | 0.1656 mL | 0.8281 mL | 1.6562 mL | 4.1405 mL | |
| 20 mM | 0.1242 mL | 0.6211 mL | 1.2421 mL | 3.1054 mL | |
| 25 mM | 0.0994 mL | 0.4969 mL | 0.9937 mL | 2.4843 mL | |
| 30 mM | 0.0828 mL | 0.4140 mL | 0.8281 mL | 2.0702 mL | |
| 40 mM | 0.0621 mL | 0.3105 mL | 0.6211 mL | 1.5527 mL | |
| 50 mM | 0.0497 mL | 0.2484 mL | 0.4969 mL | 1.2421 mL | |
| 60 mM | 0.0414 mL | 0.2070 mL | 0.4140 mL | 1.0351 mL | |
| 80 mM | 0.0311 mL | 0.1553 mL | 0.3105 mL | 0.7763 mL | |
| 100 mM | 0.0248 mL | 0.1242 mL | 0.2484 mL | 0.6211 mL |
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