A-81282
A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats.
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- No. CAS: 141872-46-0
- Fòrmula: C23H23N7O2
- Peso molecular:429.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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AT1 Receptor 9.64 (pA2) |
Chemical Information
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No. CAS 141872-46-0
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Peso molecular 429.47
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Fòrmula C23H23N7O2
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SMILES
O=C(C1=CN=CN=C1N(CCCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O
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Synonyms
Abbott 81282
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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