Adefovir-d4
Based on 1 Customer Validation
Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.69%
- No. CAS: 1190021-70-5
- Fòrmula: C8H8D4N5O4P
- Peso molecular:277.21
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-17422S1
Acyclovir-d4Stable Isotope -
HY-129983
5-Hydroxymethyl-2'-deoxyuridineNucleoside Analog -
HY-Y1055S3
Guanine-15N5Stable Isotope -
HY-W012311
3′-DeoxythymidineDNA Polymerase Inhibtior -
HY-D0186S8
2'-Deoxyuridine-d2-1Stable Isotope -
HY-B1537
AzaribineAntiviral Drug -
HY-129861
5'-Ethynyl-2'-deoxycytidineHSV Inhibitor -
HY-I0626S1
Cytosine-13C,15N2Stable Isotope -
HY-129983R
5-Hydroxymethyl-2'-deoxyuridine (Standard)Nucleoside Analog -
HY-I0960S
Uracil-13C2,15N2Stable Isotope -
HY-W010450S5
Thymine-13C5,15N2Stable Isotope
Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
No. CAS 1190021-70-5
-
Unlabeled CAS 106941-25-7
-
Appearance Solid
-
Peso molecular 277.21
-
Fòrmula C8H8D4N5O4P
-
Color White to off-white
-
SMILES
O=P(O)(O)COC([2H])([2H])C([2H])([2H])N1C2=NC=NC(N)=C2N=C1
-
Synonyms
GS-0393-d4; PMEA-d4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
-
Ficha de datos (269 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[3]. Marcellin P, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med. 2003 Feb 27;348(9):808-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adefovir-d4 Related Classifications
HY-B1826S2 Related Classifications
Powered by Bioz