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Referencia número: HY-144585

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AGD-0182

AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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No. CAS: 1835700-14-5
Fòrmula: C₃₈H₆₃N₉O₇
Peso molecular:757.96

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AGD-0182 Chemical Structure

No. CAS: 1835700-14-5

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Actividad biológica

Descripciòn

AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10^[1]. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-299	IC₅₀	0.6 nM Compound: 83a	Cytotoxicity against human KARPAS-299 cells assessed as reduction in cell viability incubated for 5 days by Presto blue dye based assay Cytotoxicity against human KARPAS-299 cells assessed as reduction in cell viability incubated for 5 days by Presto blue dye based assay	[PMID: 35072477]

Chemical Information

No. CAS 1835700-14-5
Peso molecular 757.96
Fòrmula C₃₈H₆₃N₉O₇
SMILES

CN[C@@H](C(C)C)C(N[C@@H]([C@H](C)N=[N+]=[N-])C(N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(N1[C@@H](CCC1)[C@H](OC)[C@@H](C)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O)OC)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Snyder JT, et al. Metabolism of an Oxime-Linked Antibody Drug Conjugate, AGS62P1, and Characterization of Its Identified Metabolite. Mol Pharm. 2018;15(6):2384-2390. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
- Descripciòn
Chemical Information
Pureza y Documentación
Referencias

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AGD-0182

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