Alvimopan monohydrate
Based on 2 publication(s) in Google Scholar
Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan monohydrate can be used for the research of postoperative ileus.
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- No. CAS: 1383577-62-5
- Fòrmula: C25H34N2O5
- Peso molecular:442.55
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Help & FAQs
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HY-13243
Alvimopan -
HY-101386
PZM21 -
HY-76657A
Alvimopan dihydrate -
HY-101039A
AR-M 1000390 hydrochloride -
HY-P0210
DAMGO -
HY-15708
LY2795050 -
HY-13044
ADL-5859 hydrochloride -
HY-10487
JDTic dihydrochloride -
HY-101202
SNC80 -
HY-100903
Norbinaltorphimine dihydrochloride -
HY-17417
Naloxone hydrochloride -
HY-13274
JTC-801
Publications Citing Use of MedChemExpress (MCE) Alvimopan monohydrate
MoreVer todos los productos específicos de isoformas Opioid Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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μ Opioid Receptor/MOR |
In Vitro
Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1383577-62-5
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Appearance Solid
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Peso molecular 442.55
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Fòrmula C25H34N2O5
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Color White to off-white
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SMILES
OC1=CC=CC([C@@]2(C)[C@@H](C)CN(C[C@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)CC2)=C1.O
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Synonyms
ADL 8-2698 monohydrate; LY 246736 monohydrate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12. [Content Brief]
[2]. Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83. [Content Brief]
[3]. Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alvimopan monohydrate Related Classifications
HY-76657 Related Classifications
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