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Referencia número: HY-183097

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AM89

AM89 is a PGC-1α1 stabilizer. AM89 activates the expression of PGC-1α1 target genes and induces the upregulation of Ucp1 gene expression. AM89 is applicable for the research of obesity and related metabolic disorders.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₂H₁₉NO₄S
Peso molecular:393.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AM89 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

AM89 (10 μM; 8 h) increases EGFP-PGC-1α1 fusion protein levels in stable HEK 293-EGFPmPGC-1α1 cells, with an EGFP intensity of 143.3%^[1].
AM89 (10 μM; 8 h) induces Ucp1 gene expression 5-fold and modestly increases other PGC-1α1 target gene expression in fully differentiated mouse brown adipocytes^[1].
AM89 (10 μM; 8 h) stabilizes endogenous PGC-1α1 protein in fully differentiated mouse brown adipocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

fully differentiated immortalized mouse brown adipocytes
Concentration:

10 μM
Incubation Time:

8 h
Result:

Induced a 5-fold increase in Ucp1 gene expression relative to DMSO-treated controls.
Induced small increases in the expression of other PGC-1α1 target genes including Tra2, Fsp27, Cytc, Tfam, Cpt1b, Esrra, Glut4, Prdm16, Pparg, and Sod1, though these increases were less pronounced than the Ucp1 induction.

Western Blot Analysis^[1]

Cell Line:

fully differentiated immortalized mouse brown adipocytes
Concentration:

10 μM
Incubation Time:

8 h
Result:

Stabilized endogenous PGC-1α1 protein in brown adipocytes, with protein accumulation levels comparable to other validated PGC-1α1 stabilizers.

Chemical Information

Peso molecular 393.46
Fòrmula C₂₂H₁₉NO₄S
SMILES

CC1C(/C=C2C(N(CC3=CC=C(OC)C=C3)C(S/2)=O)=O)=CC(C=CC=C4)=C4O1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Pettersson-Klein AT, et al. Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration. Mol Metab. 2018;9:28-42. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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