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Referencia número: HY-168927

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Apoptosis inducer 36

Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model.

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No. CAS: 2831492-41-0
Fòrmula: C₂₃H₄₀O₃Si
Peso molecular:392.65

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Apoptosis inducer 36 Chemical Structure

No. CAS: 2831492-41-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

Chemical Information

No. CAS 2831492-41-0
Peso molecular 392.65
Fòrmula C₂₃H₄₀O₃Si
SMILES

[H][C@@]12CC(C(O[C@@H]1CC[C@@]3([C@H](CC[C@]32[H])O[Si](C(C)C)(C(C)C)C(C)C)C)=O)=C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang J, et al., Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells. Eur J Med Chem. 2025 Feb 12;288:117360. [Content Brief]

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Topics PANoptosis: Crosstalk Between Pyroptosis, Apoptosis and Necroptosis
PANoptosis is a regulated inflammatory cell death pathway that integrates key features of pyroptosis, apoptosis, and necroptosis and cannot be fully explained by any individual pathway alone.

2026-06-18

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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