AS3566987
AS3566987 is a positive allosteric modulator of the skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3566987 promotes acetylcholine signaling via the skeletal muscle-type nicotinic acetylcholine receptor, and receptor activation requires the involvement of acetylcholine. AS3566987 can be used in the research of neuromuscular diseases (including myasthenia gravis and congenital myasthenic syndrome).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C24H16F3N5O5S2
- Peso molecular:575.54
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
AS3566987 (10 μM) acts as a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptors in Hu5/KD3 human myotubes, reducing the EC50 of ACh by 10.4-fold without inducing currents in the absence of ACh[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Peso molecular 575.54
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Fòrmula C24H16F3N5O5S2
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SMILES
FC(F)(F)C(N=C(NC(C(N1C)=C(O)C2=C(C=C(O)C=C2)S1(=O)=O)=O)S3)=C3C(C=N4)=CN=C4C5=CC=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS3566987 Related Classifications
HY-188046 Related Classifications
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