Avenanthramide B
Based on 1 publication(s) in Google Scholar
Avenanthramide B is an oat phytoalexin, a porcine liver esterase inhibitor, and an amyloglucosidase inhibitor, with an IC50 of 4.4 mg/mL against Aspergillus niger amyloglucosidase. Avenanthramide B increases the activation status of Akt1 and the expression level of eNOS, elevates the levels of NO and cGMP, and reduces the level of superoxide anions. Avenanthramide B acts on amyloglucosidase via a competitive mixed mechanism, functions as a fluorescence quencher, and exerts bidirectional regulatory effects on protein thermal stability. Avenanthramide B serves as a substrate for oat leaf peroxidase. Avenanthramide B can be used in research related to type 2 diabetes.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 108605-69-2
- Fòrmula: C17H15NO6
- Peso molecular:329.31
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Avenanthramide B
More
Actividad biológica
Descripciòn
IC50 & Target
[2]|
Akt1 |
In Vitro
Avenanthramide B (1 µM; 24 h) significantly increases intracellular NO levels and cGMP production, reduces superoxide anion generation, enhances Akt1 activation, and upregulates the protein expression level of eNOS in HUVEC cells[2].
Avenanthramide B (50 µM; 10 min) significantly inhibits the activity of porcine liver esterase[1].
Avenanthramide B (31.3-1000 μg/mL) inhibits amyloglucosidase derived from Aspergillus niger via a competitive-dominant mixed-type mechanism, with an IC50 value of 4.4 mg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HUVEC
-
Concentration:1 µM
-
Incubation Time:24 h
-
Result:Significantly increased cGMP levels compared to vehicle control.
-
Cell Line:HUVEC
-
Concentration:1 µM
-
Incubation Time:2 h
-
Result:Significantly increased the Akt1 phosphorylation/total protein ratio compared to vehicle control, indicating enhanced Akt1 activation.
Significantly increased eNOS protein expression compared to vehicle control.
Chemical Information
-
No. CAS 108605-69-2
-
Appearance Solid
-
Peso molecular 329.31
-
Fòrmula C17H15NO6
-
SMILES
C(O)(=O)C1=C(NC(/C=C/C2=CC(OC)=C(O)C=C2)=O)C=CC(O)=C1
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
Pureza y Documentación
Referencias
[1]. Lim H, et al. Compared Inhibitory Activities of Tamoxifen and Avenanthramide B on Liver Esterase and Correlation Based on the Superimposed Structure Between Porcine and Human Liver Esterase. International journal of molecular sciences. 2024 Dec 11;25(24):13291. [Content Brief]
[2]. Serreli G, et al. Ferulic Acid Derivatives and Avenanthramides Modulate Endothelial Function through Maintenance of Nitric Oxide Balance in HUVEC Cells. Nutrients. 2021 Jun 12;13(6):2026. [Content Brief]
[3]. Feng W, et al. Unraveling the inhibition mechanism of avenanthramides on amyloglucosidase: Probing by multi-spectroscopic techniques, enzyme kinetics, and molecular docking simulations. Food chemistry. 2026 Apr 30;509:148552. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Avenanthramide B Related Classifications
HY-W795967 Related Classifications
Powered by Bioz