BMS-P5
Based on 1 Customer Validation
BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.23%
- No. CAS: 1549811-36-0
- Fòrmula: C27H33ClN6O2
- Peso molecular:509.04
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
BMS-P5 blocks calcium ionophore-induced citrullination of histone H3[1].
BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Neutrophils.
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Concentration:10 µM and 100 µM.
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Incubation Time:30 min followed by addition of DP42 or 5TGM1 CM.
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Result:Prevented MM-induced NET formation.
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Syngeneic mouse model of MM[1].
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Dosage:50 mg/kg.
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Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.
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Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
Chemical Information
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No. CAS 1549811-36-0
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Appearance Solid
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Peso molecular 509.04
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Fòrmula C27H33ClN6O2
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Color Off-white to light yellow
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SMILES
O=C(N1[C@@H](C)CC[C@@H](N)C1)C2=CC(OC)=C3C(N=C(C4=CC5=CC=CN=C5N4CC6CC6)N3C)=C2.[H]Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 35 mg/mL (68.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9645 mL | 9.8224 mL | 19.6448 mL | 49.1121 mL |
| 5 mM | 0.3929 mL | 1.9645 mL | 3.9290 mL | 9.8224 mL | |
| 10 mM | 0.1964 mL | 0.9822 mL | 1.9645 mL | 4.9112 mL | |
| 15 mM | 0.1310 mL | 0.6548 mL | 1.3097 mL | 3.2741 mL | |
| 20 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4556 mL | |
| 25 mM | 0.0786 mL | 0.3929 mL | 0.7858 mL | 1.9645 mL | |
| 30 mM | 0.0655 mL | 0.3274 mL | 0.6548 mL | 1.6371 mL | |
| 40 mM | 0.0491 mL | 0.2456 mL | 0.4911 mL | 1.2278 mL | |
| 50 mM | 0.0393 mL | 0.1964 mL | 0.3929 mL | 0.9822 mL | |
| 60 mM | 0.0327 mL | 0.1637 mL | 0.3274 mL | 0.8185 mL |
BMS-P5 Related Classifications
HY-137655 Related Classifications
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