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Referencia número: HY-182603

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BO-653

BO-653 is an orally active anti-atherosclerotic antioxidant that exhibits high binding affinity for LDL. BO-653 scavenges linoleic acid peroxyl radicals, inhibits lipid peroxidation during the auto-oxidation of linoleic acid, and potently suppresses LDL oxidation. BO-653 inhibits Hepatitis C Virus (HCV) replication in a concentration-dependent manner, with an IC₅₀ of 36.0 μM against the HCV subgenomic replicon in FLR3-1 cells. BO-653 demonstrates significant anti-atherosclerotic effects in various animal models, including the Watanabe heritable hyperlipidemic rabbit. BO-653 is suitable for use in research related to atherosclerosis and Hepatitis C Virus infection.

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No. CAS: 157360-23-1
Fòrmula: C₂₆H₄₄O₂
Peso molecular:388.63

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

BO-653 Chemical Structure

No. CAS: 157360-23-1

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Actividad biológica
- Descripciòn
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

BO-653 (1f) (10 min) potently inhibits linoleic acid autoxidation in a cell-free assay with an IC₅₀ of 4.6 μM^[1].
BO-653 (24 h) inhibits both SLO‑ and CuSO₄‑induced oxidation of rabbit LDL^[1].
BO-653 (1, 10 μM; 24 h) potently reduces electrophoretic mobility changes in CuSO₄-oxidized rabbit LDL, with 1 μM treatment resulting in mobility similar to native LDL^[1].
BO-653 (1, 10 μM; 24 h) potently reduces electrophoretic mobility changes in SLO-oxidized rabbit LDL^[1].
BO-653 (12-1000 μM; 72 hours) inhibits HCV replication in a concentration-dependent manner in FLR3-1 and RMT-tri cells (IC₅₀ = 36.0 μM in FLR3-1 cells) without exhibiting cytotoxicity^[2].
BO-653 (0-1000 μM; 96 hours) reduces HCV NS3 protein levels in a concentration-dependent manner in FLR3-1 cells^[2].
BO-653 (72 hours) demonstrates stronger anti-HCV activity in FLR3-1 cells than both lipophilic and hydrophilic antioxidants^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

FLR3-1 and RMT-tri cells
Concentration:

12, 37, 111, 333, 1000 μM
Incubation Time:

72 h
Result:

Inhibited HCV replication in a concentration-dependent manner in FLR3-1 and RMT-tri cells (IC₅₀ = 36.0 μM in FLR3-1 cells) without exhibiting cytotoxicity.

Western Blot Analysis^[2]

Cell Line:

FLR3-1 cells
Concentration:

12, 37, 111, 333, 1000 μM
Incubation Time:

96 h
Result:

significantly reduced HCV NS3 protein expression in FLR3-1 cells in a concentration-dependent manner.

Immunofluorescence^[2]

Cell Line:

FLR3-1 cells
Concentration:

111 μM
Incubation Time:

72 h
Result:

Reduced HCV core protein expression.

Parmacokinetics

Species	Dose	Route	Plasma Concentration
Rabbit^[1]	250 mg/kg	p.o.	2.22 μg/mL

In Vivo

BO-653 (1f) (250 mg/kg; p.o.; once daily; 9 days) achieves high LDL concentrations in WHHL rabbits, and confers potent resistance to LDL oxidation, supporting its efficacy as an antiatherogenic antioxidant^[1].
BO-653 (2000 mg/kg; p.o.; once daily; 14 days) shows no reduction of serum HCV RNA titer in HCV-infected chimeric uPA/SCID mice, and significantly enhances the anti-HCV effect of PEG-IFN by decreasing serum and liver HCV RNA levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 157360-23-1
Peso molecular 388.63
Fòrmula C₂₆H₄₄O₂
SMILES

OC1=C(C(C)(C)C)C2=C(OC(CCCCC)(CCCCC)C2)C=C1C(C)(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Tamura K, et al. Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. J Med Chem. 2003;46(14):3083-3093. [Content Brief]

[2]. Yasui F, et al. Synthetic lipophilic antioxidant BO-653 suppresses HCV replication. J Med Virol. 2013 Feb;85(2):241-9. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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