CAY10589
CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs.
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- No. CAS: 1077626-52-8
- Fòrmula: C25H28ClN3O2S
- Peso molecular:470.03
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.3 μM
Compound: 7b
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Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
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[PMID: 19053751] |
| A549 | IC50 |
6 μM
Compound: 7b
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Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay
Inhibition of mPGES1 in human A549 cells assessed as inhibition of IL-1-beta-induced PGE2 formation by cell-intact assay
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[PMID: 19053751] |
| PMNL | IC50 |
1 μM
Compound: 7b
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Inhibition of 5-LO in PMNL cells
Inhibition of 5-LO in PMNL cells
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[PMID: 19053751] |
Chemical Information
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No. CAS 1077626-52-8
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Peso molecular 470.03
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Fòrmula C25H28ClN3O2S
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SMILES
O=C(C(CCCCCC)SC1=NC(Cl)=CC(NCC2=CC=C(C3=CC=CC=C3)C=C2)=N1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Wiegard A, et al. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1. Eur J Med Chem. 2012 Feb;48:153-63. [Content Brief]
[2]. Li L, et al. Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy. Cell Oncol (Dordr). 2023 Sep 30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CAY10589 Related Classifications
HY-117008 Related Classifications
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