CM-118
CM-118 is a potent and selective c-Met and ALK inhibitor. CM-118 inhibits the HGF-induced c-Met phosphorylation. CM-118 inhibits phosphorylation of ALK, EML4-ALKv1, ALK F1174L, and EMl4-ALKv1 L1196M, with respective IC50 values 0.92, 1.25, 1.9, and 3.5 μM. CM-118 exhibits anticancer activity against cancers dependent on the c-Met or ALK oncogenic pathways.
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- No. CAS: 1370652-56-4
- Fòrmula: C19H16Cl2FN5O3
- Peso molecular:452.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
IC50: 0.92, 1.25, 1.9, and 3.5 μM for phosphorylation of ALK, EML4-ALKv1, ALK F1174L, and EMl4-ALKv1 L1196M, respectively[1]
Chemical Information
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No. CAS 1370652-56-4
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Peso molecular 452.27
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Fòrmula C19H16Cl2FN5O3
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SMILES
C[C@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=C(N)N=NC(C(NC3=CN(C(C=C3)=O)C)=O)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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