country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-158003

Copy Link Print Information

COE-PNH2

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC₉₀ of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₅₄H₉₈Cl₈N₈O₄
Peso molecular:1207.03

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

COE-PNH2 Chemical Structure

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

COE-PNH2 (0-128 μg/mL) exhibits a stable antibacterial activity and extreme antibiotic tolerance against intracellular, replicating and nutrient-starved, non-replicating Mab^[1].
COE-PNH2 exhibits a low propensity for resistance development with consistent MIC values in 14 passages of Mab^[1].
COE-PNH2 (0-64 μg/mL) induces a depletion of ATP, accumulation of intracellular lipid inclusions (ILIs) and bacterial elongation in Mab^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

COE-PNH2 (2.5-5 mg/kg, intratracheal, every other day for 12 days) exhibits well tolerance and efficiency in acute lung infection in C3HeB/FeJ mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Acute lung infection in C3HeB/FeJ mice^[1]
Dosage:

2.5-5 mg/kg
Administration:

Intratracheal administration every other day for 12 days
Result:

Reduced the colony-forming units (CFU) and bacilli in lung without weight loss.

Chemical Information

Peso molecular 1207.03
Fòrmula C₅₄H₉₈Cl₈N₈O₄
SMILES

C[N+](C)(CCCN)CCCOC1=CC(/C=C/C2=CC=C(/C=C/C3=CC(OCCC[N+](C)(CCCN)C)=CC(OCCC[N+](C)(CCCN)C)=C3)C=C2)=CC(OCCC[N+](C)(CCCN)C)=C1.[Cl-].[Cl-].[Cl-].[Cl-].Cl.Cl.Cl.Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Zhang K, et al., An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus. Sci Transl Med. 2024 Feb 21;16(735):eadi7558. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto