DMUP
Based on 1 Customer Validation
DMUP is a potent CD47-SIRPα axis inhibitor. DMUP induces apoptosis and increases the macrophage phagocytosis in A549 cells. DMUP decreases the expression of CD47 and SIRPα protein. DMUP shows antitumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.0%
- No. CAS: 2364350-07-0
- Fòrmula: C24H24Cl2N2O10Pt
- Peso molecular:766.44
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
In Vitro
DMUP (72 h) shows antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 μM for A549, A549/DDP, PANC-1, HepG2 cells, respectively[1].
DMUP (5 μM, 24 h) arrests the cell cycle in S phase in A549 cells[1].
DMUP (5 μM, 48 h) induces apoptosis in A549 cells[1].
DMUP (5 μM, 24 h) decreases the expression of CD47 and SIRPα protein[1].
DMUP (5 μM, 4 h) increases the macrophage phagocytosis in A549-GFP cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, A549/DDP, PANC-1, HepG2 cells
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Concentration:0-64 µM
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Incubation Time:72 h
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Result:Showed antiproliferative activity with IC50s of 0.92, 3.58, 6.29, 1.54 µM for A549, A549/DDP, PANC-1, HepG2 cells, respectively.
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Cell Line:A549 cells
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Concentration:5 µM
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Incubation Time:24 h
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Result:Arrested the cell cycle in the S phase.
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Cell Line:A549 cells
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Concentration:5 µM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
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Cell Line:A549, THP-1 cells
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Concentration:5 µM
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Incubation Time:24 h
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Result:Decreased the expression of CD47 and SIRPα protein.
In Vivo
DMUP (5, 10, 20, 40 mg/kg, i.v.,every two days for 18 days) shows no toxicity in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[1]
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Dosage:5, 10, 20, 40 mg/kg
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Administration:i.v., every two days, 18 days
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Result:Showed low toxicity with LD50 of greater than 20 mg/kg.
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Animal Model:A549 xenograft BALB/c nude mice[1]
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Dosage:10 mg/kg
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Administration:i.v., every other day, 17 day
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Result:Showed antitumor activity.
Chemical Information
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No. CAS 2364350-07-0
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Appearance Solid
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Peso molecular 766.44
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Fòrmula C24H24Cl2N2O10Pt
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Color White to light yellow
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SMILES
O=C1OC2=C(C(C)=C1)C=CC(OCC([O-][Pt+4]([Cl-])([O-]C(COC3=CC(OC(C=C4C)=O)=C4C=C3)=O)([NH3])([NH3])[Cl-])=O)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMUP Related Classifications
HY-115983 Related Classifications
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