Dodecyl gallate
Based on 1 publication(s) in Google Scholar
Dodecyl gallate (Lauryl gallate) has been widely used as an antioxidant in food manufacturing, as well as in the pharmaceutical and cosmetic industries. Dodecyl gallate also acts antibacterial activity specifically against Gram-positive bacteria. Dodecyl gallate also is active against a highly relevant animal virus such as African swine fever virus (ASFV).
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- Pureza: 99.99%
- No. CAS: 1166-52-5
- Fòrmula: C19H30O5
- Peso molecular:338.44
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dodecyl gallate
More
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16-F10 | IC50 |
48 μM
Compound: G12
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Cytotoxicity against mouse B16F10 cells
Cytotoxicity against mouse B16F10 cells
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[PMID: 23291333] |
| CCRF-CEM | IC50 |
47.4 μM
Compound: G12
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Cytotoxicity against human CEM cells
Cytotoxicity against human CEM cells
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[PMID: 23291333] |
| CCRF-CEM | IC50 |
15.46 μM
Compound: LG
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Cytotoxicity against human CCRF-CEM cells after 48 hrs by neutral red assay
Cytotoxicity against human CCRF-CEM cells after 48 hrs by neutral red assay
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[PMID: 24568614] |
| CCRF-CEM | CC50 |
2.8 μM
Compound: 7
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Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation
Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation
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[PMID: 25617695] |
| CCRF-CEM | EC50 |
≥1 μM
Compound: 7
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Antiviral activity against HIV1 3B infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay
Antiviral activity against HIV1 3B infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay
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[PMID: 25617695] |
| CCRF-CEM | EC50 |
≥1 μM
Compound: 7
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Antiviral activity against HIV2 ROD infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay
Antiviral activity against HIV2 ROD infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay
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[PMID: 25617695] |
| HL-60 | IC50 |
1.1 μM
Compound: 6c
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Antiproliferative activity against human HL60 cells after 3 days
Antiproliferative activity against human HL60 cells after 3 days
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[PMID: 18693020] |
| HL-60 | IC50 |
33 μM
Compound: G12
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Cytotoxicity against human HL60 cells
Cytotoxicity against human HL60 cells
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[PMID: 23291333] |
| Huh-5-2 | CC50 |
8.9 μM
Compound: 7
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Cytotoxicity against human Huh5-2 cells after 72 hrs by MTS assay
Cytotoxicity against human Huh5-2 cells after 72 hrs by MTS assay
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[PMID: 25617695] |
| L1210 | IC50 |
10.9 μM
Compound: G12
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Cytotoxicity against mouse L1210 cells
Cytotoxicity against mouse L1210 cells
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[PMID: 23291333] |
| L929 | IC50 |
1 μM
Compound: G12
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Cytotoxicity against mouse L929 cells
Cytotoxicity against mouse L929 cells
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[PMID: 23291333] |
| MDA-MB-231 | IC50 |
1 μM
Compound: G12
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Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
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[PMID: 23291333] |
Dodecyl gallate (Lauryl gallate) is an ester derivative of gallic acid, a natural plant phenolic compound. Dodecyl gallate (Lauryl gallate) protects cells from oxidative stress, in a process associated with radical scavenging, inhibition of enzymes involved in lipid peroxidation, and increasing expression of antioxidant genes. Due to its hydrophobic properties, Dodecyl gallate can disrupt biomembranes and cause protein inactivation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1166-52-5
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Appearance Solid
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Peso molecular 338.44
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Fòrmula C19H30O5
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Color White to off-white
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SMILES
O=C(C1=CC(O)=C(C(O)=C1)O)OCCCCCCCCCCCC
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Synonyms
Lauryl gallate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Redox Biol
CRISPR-based chemogenomic profiling reveals redox vulnerabilities to epigallocatechin-3-gallate and green tea polyphenol extract. [Abstract]2026 Mar:90:104047. PMID: 41581373
Solvente y solubilidad
DMSO : 200 mg/mL (590.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9547 mL | 14.7737 mL | 29.5473 mL | 73.8683 mL |
| 5 mM | 0.5909 mL | 2.9547 mL | 5.9095 mL | 14.7737 mL | |
| 10 mM | 0.2955 mL | 1.4774 mL | 2.9547 mL | 7.3868 mL | |
| 15 mM | 0.1970 mL | 0.9849 mL | 1.9698 mL | 4.9246 mL | |
| 20 mM | 0.1477 mL | 0.7387 mL | 1.4774 mL | 3.6934 mL | |
| 25 mM | 0.1182 mL | 0.5909 mL | 1.1819 mL | 2.9547 mL | |
| 30 mM | 0.0985 mL | 0.4925 mL | 0.9849 mL | 2.4623 mL | |
| 40 mM | 0.0739 mL | 0.3693 mL | 0.7387 mL | 1.8467 mL | |
| 50 mM | 0.0591 mL | 0.2955 mL | 0.5909 mL | 1.4774 mL | |
| 60 mM | 0.0492 mL | 0.2462 mL | 0.4925 mL | 1.2311 mL | |
| 80 mM | 0.0369 mL | 0.1847 mL | 0.3693 mL | 0.9234 mL | |
| 100 mM | 0.0295 mL | 0.1477 mL | 0.2955 mL | 0.7387 mL |
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